Assessment of SNP-SNP interactions by using square contingency table analysis
Título del documento: Assessment of SNP-SNP interactions by using square contingency table analysis
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000435958
ISSN: 0001-3765
Autores: 1
2
1
Instituciones: 1Hacettepe University, Department of Statistics, Ankara. Turquía
2Bartin University, Department of Computer Technology and Information Systems, Bartın. Turquía
Año:
Volumen: 92
Número: 3
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The evolution of SNP-SNP interactions has become an interesting field in genetic epidemiology. Most of the studies, aimed to analyze the relationship between genetic factors and disease of interest, are focused on single SNP associations. However, for quantitative traits, influenced by the interplay of environmental and more than one genetic factors, interaction between the multi factors should be taken into consideration. In this study, symmetry models for square contingency tables are applied to the cross-classified SNP-SNP interactions data. Results from a genome-wide association analysis of blood pressure are used as a prior evidence for the interacted SNPs
Disciplinas: Biología,
Matemáticas
Palabras clave: Genética,
Matemáticas aplicadas,
Polimorfismos de nucleótido único (SNPs),
Análisis de interacción,
Simetría completa,
Homogeneidad marginal,
Tablas de contingencia cuadradas
Keyword: Genetics,
Applied mathematics,
Single nucleotide polymorphism (SNPs),
Interaction analysis,
Complete symmetry,
Marginal homogeneity,
Square contingency tables
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