| Revista: | Acta scientiarum. Biological sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000433509 |
| ISSN: | 1679-9283 |
| Autores: | Machado, Aline Belem1 Caprara, Juliana Foresti1 Franceschi, Itiane Diehl de2 Linden, Rafael1 Berlese, Daiane Bolzan1 Feksa, Luciane Rosa1 |
| Instituciones: | 1Universidade Feevale, Instituto de Ciencias da Saude, Novo Hamburgo, Rio Grande do Sul. Brasil 2Universidade Federal do Rio Grande do Sul, Departamento de Bioquimica, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2019 |
| Volumen: | 41 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Hexavalent chromium [Cr (VI)] is a metal utilized in different industries and consequently disposed in the environment. It is a toxic substance and its reduction to trivalent Cr [Cr (III)] generates intermediates, which are responsible for the oxidation of molecules, and cause the oxidative stress. Therefore, the aim of this study was to evaluate if Cr (VI) could induce oxidative stress in Wistar rats. In this study, Wistar rats were chronically exposed to 25 and 50 ppm of potassium dichromate in drinking water for 30 days. The levels of Cr were evaluated in the blood and tissues (liver, kidneys, and lungs). Oxidative stress was determined in the liver, kidneys, and lungs and was evaluated by DFCH, TBA-RS and carbonyl test. Antioxidant enzymes were evaluated through catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. Regarding the results, Cr concentration was significantly elevated in all tissues, however, it was lower in the lungs. In relation to the oxidative stress parameters, there was a significant increase of DCFH levels in the kidneys and carbonyls in liver and kidneys. Regarding the antioxidant enzymes, SOD was decreased in all organs and GPx was diminished in the kidneys. These data indicated that Cr (VI) could induce oxidative stress in the kidneys and liver due to an imbalance between oxidative and antioxidant parameters. The lungs were little affected, possibly by the lowest chromium accumulation |
| Disciplinas: | Biología |
| Palabras clave: | Fisiología animal, Toxicología, Contaminación del agua, Cromo hexavalente, Pruebas toxicológicas, Enzimas antioxidantes, Estrés oxidativo, Ratas |
| Keyword: | Animal physiology, Toxicology, Water pollution, Hexavalent chromium, Toxicological tests, Antioxidant enzymes, Oxidative stress, Rats |
| Texto completo: | http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/43771/pdf |
