| Revista: | The journal of venomous animals and toxins |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000298753 |
| ISSN: | 0104-7930 |
| Autores: | Lipps, B.V1 |
| Instituciones: | 1Ophidia Products Inc., Houston, Texas. Estados Unidos de América |
| Año: | 2002 |
| Volumen: | 8 |
| Número: | 2 |
| Paginación: | 255-268 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | Pharmacological substances such as adenosine deaminase (ADA), collagen, histamine, IgE, myoglobin, and nerve growth factor (NGF) are endogenously present in animals. Research from this laboratory reported decreased levels of ADA, histamine, IgE, and NGF in organs of mice injected with sub-lethal doses of cobra venom. The goal of this research is to observe the levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs of mice injected with venom from the bee Apis mellifera. Adult Balb/c female mice IM injected with half lethal dose of bee venom were sacrificed after 2 and 8 hours for removal of organs. The homogenates of the organs were assayed by ELISA for ADA, collagen, histamine, IgE, myoglobin, and NGF using respective antisera. Organs from mice injected with PBS were used as controls. It was observed that there were decreased levels of ADA, collagen, histamine, IgE, myoglobin, and NGF in certain organs after 2 h and tremendous decrease after 8 h. This is the first report showing the pharmacokinetics of ADA, collagen, histamine, IgE, myoglobin, and NGF as consequence of honeybee envenomation |
| Disciplinas: | Biología |
| Palabras clave: | Insectos, Bioquímica, Veneno de abeja, Adenosina desaminasa, Colágeno, Histamina, IgE, Mioglobina, Factor de crecimiento neuronal |
| Keyword: | Biology, Insects, Biochemistry, Bee venom, Adenosine deaminase, Collagen, Histamine, IgE, Myoglobin, Nerve growth factor |
| Texto completo: | Texto completo (Ver HTML) |
