| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290869 |
| ISSN: | 1413-8670 |
| Autors: | Kallas, Esper Georges1 Bassichetto, Katia Cristina2 Oliveira, Solange Maria3 Goldenberg, Ieda4 Bortoloto, Reginaldo5 Moreno, Diva Maria Faleiros C6 Kanashiro, Cecilia7 Chaves, Mariana Mellilo Sauer Sucupira, Maria Cecilia Araripe Diniz, Aparecido Mesquita, Fabio C |
| Institucions: | 1Universidade Federal de Sao Paulo, Divisao de Doencas Infecciosas, Sao Paulo. Brasil 2Departamento de Saude Publica de Sao Paulo, Sao Paulo. Brasil 3Henfil Counseling Testing Center, Sao Paulo. Brasil 4Specialized Attending Service in STD/Aids Campos Eliseos, Sao Paulo. Brasil 5Prevention and Attendance Center in STD/Aids Lapa, Sao Paulo. Brasil 6Pirituba Counseling Testing Center, Pirituba, Sao Paulo. Brasil 7Laboratorio Central Cidade Lapa, Sao Paulo. Brasil |
| Any: | 2004 |
| Període: | Dic |
| Volum: | 8 |
| Número: | 6 |
| Paginació: | 399-406 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating sites, of whom 384 (5.96%) tested HIV-1 positive; 43 (11.2%) of them were identified as recently infected. Twenty-two were successfully enrolled in the follow-up study, but three of them did not meet clinical and/or laboratory criteria for recent HIV-1 infection. After these exclusions, the laboratory findings revealed a median CD4+ T lymphocyte count of 585 cells/muL (inter-quartile range 25-75% [IQR], 372-754), a CD8+ T lymphocyte count of 886 cells/muL (IQR, 553-1098), a viral load of 11,000 HIV-RNA copies/mL (IQR, 3,650-78,150), log10 of 4.04 (IQR 3.56-4.88). The identification of recent HIV infections is an extremely valuable way to evaluate the spread of the virus in a given population, especially when cohort studies, considered the gold standard method to evaluate ..... |
| Disciplines | Biología, Ciencias de la computación |
| Paraules clau: | Inmunología, Virus, Redes, VIH, Infecciones, Sao Paulo |
| Keyword: | Biology, Computer science, Immunology, Virus, Networks, HIV, Infections |
| Text complet: | Texto completo (Ver HTML) |
