| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290845 |
| ISSN: | 1413-8670 |
| Autores: | Focaccia, Roberto1 Baraldo, D.C.M Ferraz, M.L.G2 Martinelli, A.L.C3 Carrilho, F.J4 Goncales-Junior, Fernando Lopes5 Pedroso, M.L.A6 Coelho, H.S.M7 Soares, J.A.S Lacerda, M.A8 Brandao, C.E9 Mattos, A.A10 Tovo, C.V Lira, L.G.C11 Zamin-Junior, Idilio12 Pinheiro, J.O.P Both, C.T |
| Instituciones: | 1Instituto Emilio Ribas, Sao Paulo. Brasil 2Universidade Federal de Sao Paulo, Sao Paulo. Brasil 3Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil 4Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil 5Universidade Estadual de Campinas, Faculdade de Ciencias Medicas, Campinas, Sao Paulo. Brasil 6Universidade Federal do Parana, Curitiba, Parana. Brasil 7Universidade Federal do Rio de Janeiro, Rio de Janeiro. Brasil 8Institutción Privada, Curitiba, Parana. Brasil 9Universidade Federal do Estado do Rio de Janeiro, Hospital Universitario Graffee Guinle, Rio de Janeiro. Brasil 10Servico de Gastroenterologia da Santa Casa de Misericordia, Porto Alegre, Rio Grande do Sul. Brasil 11Universidade Federal da Bahia, Salvador, Bahia. Brasil 12Institucion Privada, Porto Alegre, Rio Grande do Sul. Brasil 13Federal University of Rio de Janeiro, |
| Año: | 2004 |
| Periodo: | Oct |
| Volumen: | 8 |
| Número: | 5 |
| Paginación: | 348-355 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Hepatitis C virus (HCV) infection is a serious public health problem, since 80% to 85% of HCV carriers develop a persistent infection that can progress into liver cirrhosis and hepatocarcinoma. Considering that the response of hepatitis C patients to combination therapy with interferon and ribavirin depends on HCV characteristics as well as on host features, we made a retrospective analysis of demographic and anthropometrical data and HCV genotype distribution of chronic hepatitis C patients treated in public and private reference centers in Brazil. The medical records of 4,996 patients were reviewed, 81% from public and 19% from private institutions. Patients' median age was 46 years, and there was a higher prevalence of male (62%) and white patients (80%). The analysis of HCV-infecting strains showed a predominance of genotype 1 (64%) over genotypes 2 and 3. The patients' mean weight was 70.6 kg, and 65% of the patients weighed less than 77kg. Overweight and obesity were observed in 37.8% and 13.6% of the patients, respectively. Since a body weight of 75 kg or less has been considered an independent factor that significantly increases the odds of achieving a sustained virological response, the Brazilian population seems to have a more favorable body weight profile to achieve a sustained response than the American and European populations. The finding that 65% of chronic hepatitis C patients have a body weight of 77 kg or less may have a positive pharmacoeconomic impact on the treatment of genotype 1 HCV patients with weight-based |
| Disciplinas: | Biología, Medicina |
| Palabras clave: | Genética, Virus, Terapéutica y rehabilitación, Hepatitis C, Hepatitis crónica, Genotipos, Peso corporal, Farmacoeconomía |
| Keyword: | Biology, Medicine, Genetics, Virus, Therapeutics and rehabilitation, Chronic hepatitis, Hepatitis C, Genotypes, Body weight, Pharmacoeconomy |
| Texto completo: | Texto completo (Ver HTML) |
