| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290966 |
| ISSN: | 1413-8670 |
| Autors: | Machado, Adao R.L1 Arns, Clovis da Cunha2 Follador, Wilson3 Guerra, Aline |
| Institucions: | 1Instituto de Administracao Hospitalar e Ciencias da Saude do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade Federal do Parana, Hospital Clinico, Curitiba, Parana. Brasil 3Pfizer Pharmaceuticals, Sao Paulo. Brasil |
| Any: | 2005 |
| Període: | Jun |
| Volum: | 9 |
| Número: | 3 |
| Paginació: | 191-200 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Linezolid, an oxazolidinone-class antimicrobial agent, is a new drug; its use has frequently been questioned due to its high price. However, recent trials have demonstrated that the use of linezolid in mechanical ventilation-associated nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus (VAP-MRSA) may be justified due to its improved efficacy compared to vancomycin. Price and cost have different magnitudes, and clinical efficacy should always be considered in the decision-making process. Our objective was to determine whether linezolid treatment was more cost-effective than vancomycin for treating VAP-MRSA. METHODOLOGY: Elaboration of an economic model from a metanalysis of previous clinical trials comparing both drugs, through a cost-effectiveness analysis. Costs of the treatments were calculated using Brazilian parameters and were compared to the results obtained in the metanalysis. In order to compare the results with real life conditions, costs were calculated for both name brand and for generic vancomycin. RESULTS: The cost (May/2004) per unit (vial, ampoule or bag) ... |
| Disciplines | Química, Medicina |
| Paraules clau: | Química farmacéutica, Neumología, Terapéutica y rehabilitación, Linezolid, Vancomicina, Staphylococcus aureus, Neumonía, Ventiladores, Costos |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Pneumology, Therapeutics and rehabilitation, Linezolid, Vancomycin, Staphylococcus aureus, Pneumonia, Ventilators, Costs |
| Text complet: | Texto completo (Ver HTML) |
