| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290658 |
| ISSN: | 1413-8670 |
| Autores: | Mohsen, Abolhassani1 Alireza, Khabiri Sudabeh, Aslani Hiedeh, Darabi Farideh, Bagheri Mohammad-Hossein, Alimohammadian |
| Instituciones: | 1Institut Pasteur, Departement d'Immunologie, Teherán. Irán |
| Año: | 2001 |
| Periodo: | Dic |
| Volumen: | 5 |
| Número: | 6 |
| Paginación: | 345-351 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | In this report we have analysed the peripheral blood lymphocyte of several patients with chronic hepatitis B virus infection with flow cytometry. Based on the presence and absence of the HBeAb, patients were divided into two groups. In both, all the patients were HBsAg positive with normal range of serum alanine aminotranferase (23.9 ± 17.8). We have found that the immunophenotypic profiles of patients were different from healthy donors with significant decrease in CD3+ T cells, specially CD8+ T cells and a siginificant increase in the CD19+ B cells. The differences were seen in other subset of T cells (CD4+) or NK cells (CD56+/CD16+ ) and HLA-DR markers were not significant. When the phenotypic profiles of both groups were compared with each other, such changes were more dominant in group II, with HBeAb positive than in group I, with HBeAb negative. Also, we have seen a correlation between the increase of CD19+ B cells and the decrease of CD3+ T cells. No such correlation was observed with other cells |
| Disciplinas: | Biología, Química |
| Palabras clave: | Biología celular, Inmunología, Bioquímica, Virus de la hepatitis B, Infección crónica HBV, HBsAg, HBeAg, HBeAb, Subgrupo de linfocitos, Citometría de flujo |
| Keyword: | Biology, Chemistry, Cell biology, Immunology, Biochemistry, Hepatitis B virus, Chronic HBV infection, HBsAg, HBeAg, HBeAb, Lymphocyte subset, Flow cytometry |
| Texto completo: | Texto completo (Ver HTML) |
