| Revista: | The brazilian journal of infectious diseases |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000290979 |
| ISSN: | 1413-8670 |
| Autores: | Basano, S.A1 Bianco, A Taylor, W.R.J Olliaro, P2 Camargo, L.M.A |
| Instituciones: | 1Universidade de Sao Paulo, Porto Velho, Rondonia. Brasil 2World Health Organization, Special Programme for Research and Training in Tropical Diseases, Ginebra. Suiza |
| Año: | 2006 |
| Periodo: | Ago |
| Volumen: | 10 |
| Número: | 4 |
| Paginación: | 279-282 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental |
| Resumen en inglés | Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia |
| Disciplinas: | Medicina, Biología, Química |
| Palabras clave: | Terapéutica y rehabilitación, Protozoarios, Química farmacéutica, Plasmodium falciparum, Paludismo, Mefloquina |
| Keyword: | Medicine, Biology, Chemistry, Therapeutics and rehabilitation, Protozoa, Medicinal chemistry, Plasmodium falciparum, Malaria, Mefloquine |
| Texto completo: | Texto completo (Ver HTML) |
