| Revista: | Revista médica del Hospital General de México |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000439556 |
| ISSN: | 0185-1063 |
| Autors: | Gerson Cwilich, Raquel1 Shveid Gerson, Daniela1 Noguez Ramos, Alejandro1 López Zepeda, Lorena1 Rodríguez Soto, Benigno E1 Villegas Osorno, Diana A1 Valente Acosta, Benjamín2 García Guerrero, Javier2 Moreno Sánchez, Francisco2 |
| Institucions: | 1Centro Médico ABC, Departamento de Oncología Médica, Ciudad de México. México 2Centro Médico ABC, Departamento de Enfermedades Infecciosas, Ciudad de México. México |
| Any: | 2021 |
| Període: | Abr-Jun |
| Volum: | 84 |
| Número: | 2 |
| Paginació: | 64-70 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The Coronavirus disease (COVID-19) pandemic is a worldwide challenge. There are few useful tools to predict patient outcomes. Identification of biomarkers able to predict progression of the disease could improve the treatment of these patients. Objective: The objective of the study was to identify biomarkers of disease progression among patients with severe COVID-19 pneumonia. Materials and methods: A retrospective cohort study was conducted among severe COVID-19 pneumonia patients hospitalized in the American British Cowdray Medical Center in Mexico City. Disease progression was defined as use of vasoactive amines, need of non-invasive or invasive mechanical ventilation or death. Studied biomarkers included neutrophil/lymphocyte index, lymphocyte/platelet Ratio, C reactive protein, procalcitonin, D Dimer, lactic dehydrogenase (LDH), ferritin, 25–OH–Vitamin D, and interleukin 6. Results: We report 46 patients with severe COVID-19 pneumonia. Mean age was 51 years, the majority of whom 30 (65%) male. Median hospitalization was 9 days. 23 (50%) of patients presented disease progression. Ferritin and LDH were strongly associated with disease progression among our cohort. In addition, age was associated with worst prognosis with a relative risk 4.5 (1.2-16.9, p = 0.003). Conclusions: Age, ferritin, and LDH were associated with disease progression among patients with severe COVID-19 pneumonia |
| Disciplines | Medicina |
| Paraules clau: | Neumología, Diagnóstico, SARS-CoV-2, COVID-19, Biomarcadores, Deshidrogenasa láctica, Ferritina |
| Keyword: | Pneumology, Diagnosis, SARS-CoV-2, COVID-19, Biomarkers, Lactic dehydrogenase, Ferritin |
| Text complet: | https://www.hospitalgeneral.mx/frame_esp.php?id=91 |
