| Revista: | Revista médica de Chile |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000423847 |
| ISSN: | 0034-9887 |
| Autors: | Miranda Díaz, Alejandra G1 Hermosillo Sandoval, José Manuel2 Huerta-Rosas, Gonzalo López Guillén, Germán2 Cardona Muñoz, Ernesto G1 García Iglesias, Trinidad1 Pacheco Moisés, Fermín3 Alatorre-Carranza, María del P1 |
| Institucions: | 1Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México 2Instituto Mexicano del Seguro Social, Centro Médico Nacional de Occidente, Guadalajara, Jalisco. México 3Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e Ingeniería, Guadalajara, Jalisco. México |
| Any: | 2019 |
| Període: | Oct |
| Volum: | 147 |
| Número: | 10 |
| Paginació: | 1259-1263 |
| País: | Chile |
| Idioma: | Español |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Background: During cholecystectomy, the bile duct may be injured. When this complication occurs, Kupffer cells are activated and produce tumor necrosis factor alpha (TNF-a) and interleukin-6 (IL6) to phagocyte toxic products Aim: To measure serum levels of TNF-a and IL-6 among patients that suffered a bile duct injury after a cholecystectomy. Patients and Methods: Serum levels of TNF-a and IL-6 were measured prior to the bile-enteric derivation and after one year of follow-up, in 31 patients that had a complete bile duct obstruction after open or laparoscopic cholecystectomy and in 5 healthy controls. Results: At baseline TNF-a levels in healthy subjects and patients with bile duct injury were 0 and 43.9 ± 2.9 ng/mL, respectively (p < 0.01). At one year of follow up, TNF-a became undetectable among patients. At baseline, the values for IL-6 among healthy controls and patients were 3.0 ± 2.0 and 72.0 ± 94.7 pg/mL respectively, (p < 0,004). After one year of follow up, IL-6 levels decreased to 6.4 ± 0.3 pg/mL among patients. Conclusions: TNF-a and IL-6 levels were elevated before bile-enteric derivation among patients with bile duct injury and became normal one year later |
| Disciplines | Medicina, Demografía |
| Paraules clau: | Gastroenterología, Terapéutica y rehabilitación, Características de la población, Conductos biliares extrahepáticos, Interleucina-6, Factor de necrosis tumoral alfa |
| Keyword: | Gastroenterology, Therapeutics and rehabilitation, Demographics, Bile ducts extrahepatic, Interleukin-6, Tumor necrosis factor-alpha |
| Text complet: | Texto completo (Ver PDF) |
