| Revista: | Revista latinoamericana de hipertensión |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000437473 |
| ISSN: | 1856-4550 |
| Autors: | Pestana, Carolina1 Lares, Mary2 Brito, Sara2 Porco, Antonieta1 |
| Institucions: | 1Universidad Simón Bolívar, Departamento de Biología Celular, Caracas, Distrito Federal. Venezuela 2Hospital Militar "Dr. Carlos Arvelo", Servicio de Endocrinología, Caracas, Distrito Federal. Venezuela |
| Any: | 2010 |
| Volum: | 5 |
| Número: | 3 |
| Paginació: | 53-57 |
| País: | Venezuela |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Detection of the ACE I/D polymorphism genotype and the association with essential hypertension and acute myocardial infarction (AMI) in the Venezuelan population. Methods: Samples from 200 patients with AMI and 200 control subjects were analyzed for genotyping ACE I/D polymorphism. A subset of 82 samples underwent the determination of angiotensin II levels (pg/ml). Results: The frequency for the heterozygous ID was 52.50% vs 44.50% and 26.50% vs 36.00% for DD homozygous individuals for AMI and control groups respectively. The D allele frequency was very similar for both populations (0.535 for AMI vs 0.583 for control subjects). The OR for AMI in carriers for the D allele was 0.91 (95% CI: 0.54- 1.53, p>0.05). We found a 2.66 fold increased risk between individuals belonging to the AMI group (OR= 2.66, 95% CI: 1.33-5.31, p<0.05) and an 8.46 fold increased risk for AMI in hypertensive individuals (OR=8.46, 95% CI: 5.24-1368; p<0.05). Finally, we detected a statistically significant difference in angiotensin II levels between individuals with DD and II genotypes (6.59±2.93 pg/ml DD genotype vs 4.26±1.40 pg/ml II genotype, p<0.05).Conclusions: We did not find the ACE genotype as a marker for AMI; but we found at statistically significant increased risk between hypertensive individuals carrying the D allele belonging to the AMI group. The lack of direct association between D risk allele and the AMI could be due to the well known multifactorial nature of this pathology |
| Disciplines | Medicina |
| Paraules clau: | Sistema cardiovascular, Angiotensina, Regulación genética, Polimorfismo genético, Riesgo cardiovascular, Infarto agudo del miocardio |
| Keyword: | Cardiovascular system, Angiotensin, Genetic regulation, Genetic polymorphism, Cardiovascular risk, Myocardial acute infarction |
| Text complet: | http://biblat.unam.mx/hevila/Revistalatinoamericanadehipertension/2010/vol5/no3/2.pdf |
