| Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000187498 |
| ISSN: | 0036-4665 |
| Autors: | Linhares, Alexandre C1 Karmo, Kenea B. do Oliveira, Krynssya K Oliveira, Consuelo S Freitas, Ronaldo B. de Bellesi, Newton Monteiro, Talita A.F Gabbay, Yvone B Mascarenhas, Joana D'Arc P |
| Institucions: | 1Fundacao Nacional de Saude, Belem, Para. Brasil |
| Any: | 2002 |
| Període: | Ene-Feb |
| Volum: | 44 |
| Número: | 1 |
| Paginació: | 13-16 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | The rhesus-human reassortant, tetravalent rotavirus vaccine (RRV-TV) was licensed for routine use in the United States of America but it was recently withdrawn from the market because of its possible association with intussusception as an adverse event. The protective efficacy of 3 doses of RRV-TV, in its lower-titer (4 x 104 pfu/dose) formulation, was evaluated according to the nutritional status of infants who participated in a phase III trial in Belém, Northern Brazil. A moderate protection conferred by RRV-TV was related to weight-for-age Z-scores (WAZ) greater than -1 only, with rates of 38% (p = 0.04) and 40% (p = 0.04) for all- and- pure rotavirus diarrhoeal cases, respectively. In addition, there was a trend for greater efficacy (43%, p = 0.05) among infants reaching an height-for-age Z-score (HAZ) of > -1. Taking WAZ, HAZ and weight-for-height Z-score (WHZ) indices £ -1 together, there was no significant protection (p > 0.05) if both placebo and vaccine groups are compared. There was no significant difference if rates of mixed and pure rotavirus diarrhoeal cases are compared in relation to HAZ, WAZ and weight-for-height Z-score (WHZ) indices. Although a low number of malnourished infants could be identified in the present study, our data show some evidence that malnutrition may interfere with the efficacy of rotavirus vaccines in developing countries |
| Disciplines | Medicina |
| Paraules clau: | Metabolismo y nutrición, Salud pública, Inmunología, Vacunas, Rotavirus, Estado nutricional, Eficacia |
| Keyword: | Medicine, Metabolism and nutrition, Public health, Vaccines, Rotavirus, Nutritional status, Efficacy, Immunology |
| Text complet: | Texto completo (Ver PDF) |
