| Revista: | Revista do Instituto de Medicina Tropical de Sao Paulo |
| Base de datos: | |
| Número de sistema: | 000537152 |
| ISSN: | 0036-4665 |
| Autors: | Oliveira, Claudia Di Lorenzo1 Cardoso, Clareci Silva1 Baldoni, Nayara Ragi1 Natany, Larissa2 Ferreira, Ariela Mota3 Oliveira, Lea Campos de4 Nunes, Maria do Carmo Pereira2 Quintino, Nayara Dornela1 Bierrenbach, Ana Luiza5 Buss, Lewis F.4 Haikal, Desiree Sant’Ana3 Cunha Neto, Edecio7 Ribeiro, Antonio Luiz Pinho2 Sabino, Ester Cerdeira4 |
| Institucions: | 1Universidade Federal de São João del-Rei, Divinópolis, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais. Brasil 3Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais. Brasil 4Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo. Brasil 5Hospital Sírio-Libanês, São Paulo, São Paulo. Brasil 6Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás. Brasil 7Universidade de São Paulo, Faculdade de Medicina, São Paulo, São Paulo. Brasil |
| Any: | 2021 |
| Volum: | 63 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | The SaMi-Trop project is a cohort study conducted in 21 municipalities of endemic areas of Chagas disease, including 1,959 patients with chronic Chagas cardiomyopathy. In this article we updated the results of the project, adding information from the second cohort visit. Trypanosoma cruzi-seropositive patients were enrolled from the primary care Telehealth service in Minas Gerais State, Brazil. The eligibility criterium for the second visit was the participation in the baseline evaluation. Of 1,959 participants at the baseline assessment, 1,585 (79.9%) returned after two years for the second evaluation. The mortality rate was 6.7%, but varied from 0.9% to 18.2% when it was stratified by certain clinical characteristics. A lower age-adjusted NT-Pro-BNP level (less than 300) and a prior benznidazole treatment were associated with lower mortality. There was an improvement in most quality of life domain scores. Participants have also reported fewer signs and symptoms and greater use of medication. The second follow-up visit will be complete in Oct 2021. |
| Keyword: | Chagas disease, Neglected diseases, Chagas cardiomyopathy, Cohort studies |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
