Circumsporozoite Surface Protein-based malaria vaccines: a review



Título del documento: Circumsporozoite Surface Protein-based malaria vaccines: a review
Revista: Revista do Instituto de Medicina Tropical de Sao Paulo
Base de datos:
Número de sistema: 000537083
ISSN: 0036-4665
Autors: 1
1
4
1
Institucions: 1Fiocruz Amazônia, Instituto Leônidas e Maria Deane, Amazonas, Manaus. Brasil
2Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro. Brasil
3Centro Universitário Fametro, Manaus, Amazonas. Brasil
4Universidade Federal do Amazonas, Instituto de Ciências Biológicas, Manaus, Amazonas. Brasil
5Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas, Manaus. Brasil
Any:
Volum: 63
País: Brasil
Idioma: Inglés
Resumen en inglés Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradication and control of this disease. Researches aimed at developing vaccines have focused on antigens of high importance for the survival of the parasite such as the Circumsporozoite Surface Protein, involved in the pre-erythrocytic cycle during parasites invasion in hepatocytes. Currently, RTS’S is the most promising vaccine for malaria and was constructed using CSP; its performance was evaluated using two types of adjuvants: AS01 and AS02. The purpose of this review was to provide a bibliographic survey of historical researches that led to the development of RTS’S and its performance analysis over the decade. The search for new adjuvants to be associated with this antigen seems to be a way to obtain higher percentages of protection for a future malaria vaccine.
Keyword: Malaria,
Vaccine,
Adjuvant,
Circumsporozoite Surface Protein
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