Association of TAP1 1177A>G and 2090A>G gene polymorphisms with latent tuberculosis infections in sheltered populations, in the metropolitan area of Guadalajara, Mexico: a pilot study
Título del documento: Association of TAP1 1177A>G and 2090A>G gene polymorphisms with latent tuberculosis infections in sheltered populations, in the metropolitan area of Guadalajara, Mexico: a pilot study
Revista: Revista do Instituto de Medicina Tropical de Sao Paulo
Base de datos:
Número de sistema: 000537133
ISSN: 0036-4665
Autors: 1
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Institucions: 1Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud Guadalajara, Guadalajara. México
2Universidad de Guadalajara, Centro Universitario de los Valles, Ameca. México
3Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara. México
4Secretaria de Salud Jalisco, Centro de Salud Tonalá, Guadalajara, Jalisco. México
5Universidad de Guadalajara, Centro Universitario de la Ciénega, Ocotlán. México
Any:
Volum: 63
País: Brasil
Idioma: Inglés
Resumen en inglés Latent tuberculosis infection (LTBI) is a condition that has no clinical signs and symptoms. LTBI patients are characterized by persistent immune responses to Mycobacterium tuberculosis, and approximately 5-10% of these infected individuals will develop active TB at some point in their lives. The antigen transporter associated with antigen processing (TAP1) is a protein involved in the transport of the antigen from the cytoplasm to the endoplasmic reticulum by means of the association with MHC class I molecules. It plays a fundamental role in the immune response, promoting the clearance of intracellular pathogens. Our pilot study aimed to determine the association between TAP1 gene 1177A>G (rs1057141) and 2090A>G (rs1135216) genetic polymorphisms with susceptibility to LTBI. In this case-control study, 153 individuals from shelters were analyzed (46 were LTBI-positive and 92 were controls). Genotyping of the rs11352216 (2090A>G) and rs1057141 (1177A>G) gene IDs was performed using the Applied Biosystems Step One Thermal Cycler Real-Time PCR allelic discrimination technology. The haplotypic analyses were performed with the Arlequin 3.5 program. Social assistance centers and shelters that serve vulnerable populations represent high-risk sites due to overcrowding and the impaired nutritional status of their residents. The G allele (OR=1.99, CI=1.109-3.587, p=0.021) and the GG genotype of rs11352216 (A>G) were associated with susceptibility to LTBI, according to the codominant genetic model (OR=8.32, CI=1.722-61.98, p=0.007). The rs1057141 (A>G) polymorphism was not associated with LTBI risk. The results suggest that carriers of the G allele of rs1135216 (A>G) are susceptible to LTBI.
Keyword: Latent tuberculosis infection,
Genetic susceptibility,
Mycobacterium tuberculosis,
TAP1
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