| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454103 |
| ISSN: | 0034-8376 |
| Autores: | Ramírez Bello, Julian1 Vargas Alarcón, Gilberto2 Pérez Méndez, Óscar2 Martínez Ríos, Marco A3 Peña Duque, Marco A3 Cardoso Saldaña, Guillermo4 Posadas Romero, Carlos4 Sierra Martínez, Mónica5 Fragoso, José M2 |
| Instituciones: | 1Hospital Juárez de México, Unidad de Investigación, Ciudad de México. México 2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Biología Molecular, Ciudad de México. México 3Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Cardiología Intervencionista, Ciudad de México. México 4Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Endocrinología, Ciudad de México. México 5Hospital Juárez de México, Laboratorio de Genética y Diagnóstico Molecular, Ciudad de México. México |
| Año: | 2020 |
| Periodo: | Ene-Feb |
| Volumen: | 72 |
| Número: | 1 |
| Paginación: | 19-24 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Background: Previous studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS). Objective: The objective of the study was to study the role of three polymorphisms in the BAT1, NFKBIL1, and LTA genes on the susceptibility or protection against ACS; we included a group of cases-controls from Central Mexico. Methods: The BAT1 rs2239527C/G, NFKBIL1 rs2071592T/A, and LTA rs1800683G/A polymorphisms were genotyped using a 5’ TaqMan assay in a group of 625 patients with ACS and 617 healthy controls. Results: Under a recessive model, the BAT1 -23C/G (rs2239527) polymorphism showed an association with protection against ACS (odds ratio = 0.56, and p-corrected = 0.019). In contrast, the genotype and allele frequencies of the NFKBIL1 rs2071592T/A and LTA rs1800683G/A polymorphisms were similar between ACS patients and controls and no association was identified. Conclusion: Our data suggest an association between the BAT1 -23C/G polymorphism and protection against ACS in Mexican patients |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Bioquímica, Síndrome coronario agudo, Transaminasas, Polimorfismos de nucleótido único (SNPs) |
| Keyword: | Cardiovascular system, Biochemistry, Acute coronary syndrome, Transaminases, Single nucleotide polymorphism (SNPs) |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
