Result Turnaround Time of RT-PCR for SARS-CoV-2 is the Main Cause of COVID-19 Diagnostic Delay: A Country-Wide Observational Study of Mexico and Colombia
Título del documento: Result Turnaround Time of RT-PCR for SARS-CoV-2 is the Main Cause of COVID-19 Diagnostic Delay: A Country-Wide Observational Study of Mexico and Colombia
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000452983
ISSN: 0034-8376
Autors: 1
3
2
Institucions: 1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Educación Médica, Ciudad de México. México
2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Enfermedades Infecciosas, Ciudad de México. México
3National Institutes of Health, National Institute of Allergy and Infectious Diseases,, Bethesda. Estados Unidos
Any:
Període: Mar-Abr
Volum: 74
Número: 2
Paginació: 71-80
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés Delay in COVID-19 diagnosis due to late real-time reverse transcription-polymerase chain reaction reporting has been described to be an important cause of suboptimal COVID-19 surveillance and outbreak containment. Objective: The objective of the study was to determine the duration of diagnostic delay due to test turnaround time and its association with marginalization status. Methods: In this observational study using national open data of Mexico and Colombia, we quantified the delay in COVID-19 diagnosis that occurred in both countries. We considered two periods that contributed to the delay in diagnosis: the time from symptom onset until testing (delay-one) and test turnaround time (delay-two). Marginalization status was determined according to country-specific scores. Results: Among 3,696,773 patients from Mexico and Colombia, delay-two was generally longer than delay-one. Median delay-one was 3 days and delay-two 7 days in Colombia, while in Mexico, they were 3 days and 4 days, respectively. In Colombia, worse marginalization status prolonged delay-two. In Mexico, a lower number and percentage of rapid tests were performed in areas with worse marginalization. Conclusion: Diagnostic delay was mostly due to test turnaround time. Marginalization status was an important barrier to diagnostic test access
Disciplines Medicina
Paraules clau: Diagnóstico,
SARS-CoV-2,
COVID-19,
Reacción en cadena de la polimerasa (PCR)
Keyword: Diagnosis,
SARS-CoV-2,
COVID-19,
Polymerase chain reaction (PCR)
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