Resection of the Atrial Appendages and its Impact in the Natriuretic Homeostasis: Development and Validation of an Animal Model in an Academic Medical Center
Título del documento: Resection of the Atrial Appendages and its Impact in the Natriuretic Homeostasis: Development and Validation of an Animal Model in an Academic Medical Center
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000454092
ISSN: 0034-8376
Autores: 1
2
3
4
5
4
1
6
7
Instituciones: 1Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Inmunología, Ciudad de México. México
2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Investigación en Medicina Social, Ciudad de México. México
3Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Cirugía, Ciudad de México. México
4Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Anestesiología, Ciudad de México. México
5Instituto Nacional de Cardiología Ignacio Chávez, Bioterio, Ciudad de México. México
6Instituto Nacional de Cardiología Ignacio Chávez, División de Investigación, Ciudad de México. México
7Radboud University Medical Center Nijmegen, Department of Cardiology, Nijmegen, Gelderland. Países Bajos
Año:
Periodo: Mar-Abr
Volumen: 72
Número: 2
Paginación: 103-109
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The left atrial appendage (LAAp) resection is an effective treatment approach to reduce the risk of thromboembolism in patients with atrial fibrillation. Objective: To study was to study the impact of removing atrial appendages in the production of natriuretic peptides (NPs) in conditions of volume overload and to develop an experimental model of LAAp resection. Materials and Methods: In a swine model of ischemic heart failure (HF), serum NP levels were measured before (Basal-1A) and after (Basal-1B) a fluid overload. Animals were grouped as follows: (0) preserved appendages, (1) resected LAAp, and (2) both atrial appendages resected. Levels of NP were measured before (2A) and after a fluid overload (2B). Results: Furin levels were higher in Group 0-2A than in Group 2-2A, and a significant increase was found in Group 0-2B compared to Groups 1-2B and 2-2B. Corin levels increased in Basal-1B versus Basal-1A. Atrial NP (ANP) decreased in Basal-1B compared to Basal-1A. After HF induction, ANP increased in Groups 2-2A and 2-2B. Conclusions: Resection of atrial appendages drastically modifies the natriuretic mechanisms of cardiac homeostasis, especially after a fluid overload challenge. Herein, we describe the face and predictive validation of an animal model of atrial appendage resection useful to investigations in translational medicine
Disciplinas: Medicina
Palabras clave: Sistema cardiovascular,
Cirugía,
Fibrilación auricular,
Falla cardiaca,
Péptidos natriuréticos,
Apéndices auriculares,
Resección quirúrgica
Keyword: Cardiovascular system,
Surgery,
Atrial fibrillation,
Heart failure,
Natriuretic peptides,
Atrial appendage,
Surgical resection
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