| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000389658 |
| ISSN: | 0034-8376 |
| Autors: | González Maciel, Angélica1 Romero Velázquez, Rosa María1 Reynoso Robles, Rafael1 Uribe Escamilla, Rebeca2 Vargas Sánchez, Javier2 Garza Montaño, Paloma de la2 Alfaro Rodríguez, Alfonso2 |
| Institucions: | 1Instituto Nacional de Pediatría, Departamento de Hematología y Oncología, Tlalpan, Distrito Federal. México 2Instituto Nacional de Rehabilitación, División de Neurociencias, México, Distrito Federal. México |
| Any: | 2015 |
| Període: | Sep-Oct |
| Volum: | 67 |
| Número: | 5 |
| Paginació: | 296-303 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | Prenatal protein malnutrition disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local gamma-aminobutyric acid interneurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the gamma-aminobutyric acid cell population of prenatal protein malnutrition rats. Objective: This experimental study was conducted to ascertain the effects of prenatal protein malnutrition on the density of GABAergic interneurons at the cornus ammonis and fascia dentata in rats. Methods: Animals were investigated under two nutritional conditions: (i) prenatal protein malnutrition group fed 6% protein, and (ii) well-nourished control group fed 25% protein. Using an antibody for gamma-aminobutyric acid, immunoreactive cells (GABAergic) were assessed in the rostral-caudal direction of the dorsal hippocampus at four levels. Results: (i) In 30-day-old rats with prenatal malnutrition, the fascia dentata had an average of 27% more GABAergic cells than the control group; this higher amount was not detectable at 90 days. (ii) There was a significant 18% increase in GABAergic neurons at level 1 of the cornus ammonis at 90 days of age. Conclusions: There was an increase in the population of interneurons in the fascia dentata and cornus ammonis in prenatal protein malnutrition rats. We conclude that prenatal hypoprotein malnutrition produces changes at 30 days in the fascia dentata. Results suggest that prenatal malnutrition also produces a delay in the programmed chronology of gamma-aminobutyric acid interneurons. Finally, in cornus ammonis, at 90 days of age, prenatal protein malnutrition showed an increase only at level 1; this effect may be evidenced in the long term, despite postnatal rehabilitation. ( |
| Disciplines | Medicina |
| Paraules clau: | Metabolismo y nutrición, Neurología, Pediatría, Cornus ammonis, Fascia dentada, Hipocampo, Desnutrición intrauterina, Neuronas gabaérgicas |
| Keyword: | Medicine, Metabolism and nutrition, Neurology, Pediatrics, Cornus ammonis, Fascia dentata, Hippocampus, Intrauterine malnutrition, Gabaergic neurons |
| Text complet: | Texto completo (Ver PDF) |
