| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000390746 |
| ISSN: | 0034-8376 |
| Autors: | Córdova Pérez, Nydia1 Basurto Acevedo, Lourdes1 Degollado Córdova, José Antonio1 Saucedo García, Renata Patricia1 Martínez Murillo, Carlos1 Zárate Treviño, Arturo1 Vázquez Martínez, Ana Laura1 Vega García, Sara1 Díaz Martínez, Alma Grisel1 Borrayo Sánchez, Gabriela2 Reyes Maldonado, Elba3 |
| Institucions: | 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, México, Distrito Federal. México 2Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, México, Distrito Federal. México 3Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, México, Distrito Federal. México |
| Any: | 2015 |
| Període: | Mar-Abr |
| Volum: | 67 |
| Número: | 2 |
| Paginació: | 122-129 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Estadística o encuesta |
| Enfoque: | Analítico |
| Resumen en inglés | PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels. Objective: The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease. Material and Methods: A cross-sectional study was conducted in 142 women aged 45 to 60 years with no history of cardiovascular disease. Anthropometric and laboratory measurements were performed, including PAI-1 levels. All participants underwent a B-Mode ultrasound to measure intima-media thickness. Subclinical atherosclerosis was considered when intima-media thickness was ≥ 0.7 mm and/or an atheromatous plaque was observed. Results: Postmenopausal women had greater intima-media thickness than premenopausal women (0.688 ± 0.129 vs. 0.621 ± 0.113 mm; p < 0.05). Compared to women with normal intima-media thickness, women with subclinical atherosclerosis had higher PAI-1 levels (23.2 ± 13.7 vs. 30.4 ± 20.7 ng/ml; p < 0.05). In all participants, intima-media thickness correlated with PAI-1 (r = 0.302; p = 0.01) and with age (r = 0.358; p = 0001). Conclusions: An increase in intima-media thickness was observed in postmenopausal women compared with premenopausal women. Asymptomatic women with increased intima-media thickness had higher PAI-1 levels. These findings suggest that fibrinolytic activity is low in the subclinical stage of atherosclerosis |
| Disciplines | Medicina |
| Paraules clau: | Ginecología y obstetricia, Sistema cardiovascular, Aterosclerosis, Fibrinólisis, Menopausia, Carótida, Inhibidor del activador de plasminógeno, Espesor |
| Keyword: | Medicine, Cardiovascular system, Gynecology and obstetrics, Atherosclerosis, Fibrinolysis, Menopause, Carotid artery, Thickness, Plasminogen activator inhibitor |
| Text complet: | Texto completo (Ver PDF) |
