Insulin-Like growth factor binding Protein-1, non-alcoholic fatty liver disease, and its relationship with fructose consumption in children with obesity
Título del documento: Insulin-Like growth factor binding Protein-1, non-alcoholic fatty liver disease, and its relationship with fructose consumption in children with obesity
Revista: Revista de investigación clínica
Base de datos: PERIÓDICA
Número de sistema: 000454129
ISSN: 0034-8376
Autores: 1
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Instituciones: 1Universidad de Guanajuato, Departamento de Ciencias Médicas, León, Guanajuato. México
Año:
Periodo: Sep-Oct
Volumen: 71
Número: 5
Paginación: 339-348
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Background Over consumption of added sugar is associated with obesity, non-alcoholic fatty liver disease (NAFLD), and insulin resistance (IR). Objective The objective of the study was to study the insulin-like growth factor binding protein-1 (IGFBP-1) and NAFLD and their relationship with fructose consumption in children with obesity. Methods A cross-sectional study was carried out in children 6-11 years old with obesity. Anthropometric measurements, fructose consumption, glucose, lipid profile, insulin, and IGFBP-1 levels were evaluated; the homeostatic model assessment of IR (HOMA-IR) was used. NAFLD was evaluated by ultrasound. Results We studied 83 children with a mean age of 9.2 ± 1.3 years. About 93% of the girls presented IR and lower levels of IGFBP-1 (p = 0.0001). The group with the lower levels of IGFBP-1 had higher HOMA-IR (p = 0.000002); IGFBP-1 was associated with fructose consumption (r = −0.25; p = 0.03), body mass index (BMI) (r=−0.42; p = 0.02), and HOMA-IR (r=−0.61; p = 0.002). About 81% of the children were classified as having mild or moderate/severe NAFLD, and these groups had higher HOMA-IR (p = 0.036) and fructose consumption (p = 0.0014). Conclusions The girls had more metabolic alterations. The group with lower levels of IGFBP-1 (hepatic IR) was associated with higher BMI, HOMA-IR, and fructose consumption; the group with higher severity of NAFLD showed higher HOMA-IR and fructose consumption
Disciplinas: Medicina
Palabras clave: Metabolismo y nutrición,
Pediatría,
Niños,
Obesidad,
Ingesta de fructosa,
Resistencia a la insulina,
Hígado graso no alcohólico
Keyword: Metabolism and nutrition,
Pediatrics,
Children,
Fructose intake,
Obesity,
Insulin resistance,
Non alcoholic fatty liver
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