| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000453221 |
| ISSN: | 0034-8376 |
| Autores: | Olivares Gazca, Juan C1 Priesca Marín, José M1 Ojeda Laguna, Martín1 Garces Eisele, Javier2 Soto Olvera, Silvia3 Palacios Alonso, Abraham4 Izquierdo Vega, Judith4 Chacon Cano, Rómulo5 Arizpe Bravo, Daniel5 López Trujillo, Miguel A3 Cantero Fortiz, Yahveth1 Fernandez Lara, Danitza1 Ruiz Delgado, Guillermo J1 Ruiz Argüelles, Guillermo J1 |
| Instituciones: | 1Clínica Ruiz de Puebla, Centro de Hematología y Medicina Interna, Puebla. México 2Universidad Popular Autónoma del Estado de Puebla, Puebla. México 3Clínica Ruiz de Puebla, Laboratorios Ruiz, Puebla. México 4Hospital Puebla, Puebla. México 5Hospital Angeles Puebla, Puebla. México |
| Año: | 2020 |
| Periodo: | May-Jun |
| Volumen: | 72 |
| Número: | 3 |
| Paginación: | 159-164 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Background: The ideal treatment of coronavirus disease (COVID)-19 has yet to be defined, but convalescent plasma (CoPla) has been successfully employed. Objective: The objective of the study was to study the safety and outcomes of the administration of CoPla to individuals with severe COVID-19 in an academic medical center. Methods: Ten patients were prospectively treated with plasma from COVID-19 convalescent donors. Results: Over 8 days, the sequential organ failure assessment score dropped significantly in all patients, from 3 to 1.5 (p = 0.014); the Kirby index (PaO2/FiO2) score increased from 124 to 255, (p < 0.0001), body temperature decreased significantly from 38.1 to 36.9°C (p = 0.0058), and ferritin levels also dropped significantly from 1736.6 to 1061.8 ng/ml (p = 0.0001). Chest X-rays improved in 7/10 cases and in 6/10, computerized tomography scans also revealed improvement of the lung injury. Decreases in C-reactive protein and D-dimer levels were also observed. Three of five patients on mechanical ventilation support could be extubated, nine were transferred to conventional hospital floors, and six were sent home; two patients died. The administration of CoPla had no side effects and the 24-day overall survival was 77%. Conclusions: Although other treatments were also administered to the patients and as a result data are difficult to interpret, it seems that the addition of CoPla improved pulmonary function |
| Disciplinas: | Medicina |
| Palabras clave: | Neumología, Terapéutica y rehabilitación, COVID-19, SARS-CoV-2, Infusiones, Plasma |
| Keyword: | Pneumology, Therapeutics and rehabilitation, COVID-19, SARS-CoV-2, Infusions, Plasma |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
