| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313172 |
| ISSN: | 0100-4042 |
| Autors: | Moreno, Ruben G.M1 Alipazaga, María V Medeiros, Marisa H.G Coichev, Nina |
| Institucions: | 1Universidade de Sao Paulo, Instituto de Quimica, Sao Paulo. Brasil |
| Any: | 2006 |
| Període: | Sep |
| Volum: | 29 |
| Número: | 5 |
| Paginació: | 1086-1093 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | The oxidation of sulfite catalyzed by transition metal ions produces reactive oxysulfur species that can damage plasmid and isolated DNA in vitro. Among the four DNA bases, guanine is the most sensitive to one-electron oxidation promoted by the species formed in the autoxidation of sulfite (HSO5-, HO, SO3-, SO4- and SO5-) due to its low reduction potential and ability to bind transition metal ions capable to catalyze oxidative processes. Some oxidative DNA lesions are promutagenic and oxidative DNA damage is proposed to play a crucial role in certain human pathologies, including cancer |
| Disciplines | Química, Medicina |
| Paraules clau: | Bioquímica, Toxicología, Genética, ADN, Desdoblamiento, Radical oxisulfuro, Potencial mutagénico |
| Keyword: | Chemistry, Medicine, Biochemistry, Toxicology, Genetics, DNA, Cleavage, Oxysulfur radical, Mutagenic potential |
| Text complet: | Texto completo (Ver HTML) |
