| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313332 |
| ISSN: | 0100-4042 |
| Autors: | Melo, Julio O.F1 Donnici, Claudio Luis2 Augusti, Rodinei Ferreira, Vitor F3 Souza, Maria Cecilia B.V. de Ferreira, Maria Lourdes G Cunha, Anna C |
| Institucions: | 1Universidade do Estado de Minas Gerais, Centro Universitario de Patos de Minas, Patos de Minas, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal Fluminense, Instituto de Quimica, Niteroi, Rio de Janeiro. Brasil |
| Any: | 2006 |
| Període: | Jun |
| Volum: | 29 |
| Número: | 3 |
| Paginació: | 569-579 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Descriptivo, divulgación |
| Resumen en inglés | The 1,2,3-triazole, known since the end of 19th century, is a very widely used heterocyclic system present in many synthetic substances and commercial pharmaceutical compounds. In fact, 1,2,3-triazoles show several applications in many areas especially as medicines against many diseases like cancer, AIDS, Parkinson and Alzheimer. Nowadays there is a large variety of known methods to obtain these heterocyclic compounds comprising mainly three synthetic routes. Nevertheless, there is no article that gives an objective overview of the synthetic methods for obtaining these kinds of azoheterocycles. This paper presents a brief history of this class of compounds, and a synthetic discussion concerning the main synthetic methods for its preparation, such as cyclization through hydrazones, concerted cycloadditon [2+3] and pseudopericyclic cyclization - and some others of restricted application, but also important. Finally, this paper also provides a brief overview on pharmacological applications of some 1,2,3-triazoles |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Triazol, Síntesis química, Farmacología |
| Keyword: | Chemistry, Medicinal chemistry, Triazole, Chemical synthesis, Pharmacology |
| Text complet: | Texto completo (Ver HTML) |
