| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313203 |
| ISSN: | 0100-4042 |
| Autors: | Silveira, Gustavo Pozza1 Nome, Faruk Gesser, Jose Carlos Sa, Marcus Mandolesi Terenzi, Hernan2 |
| Institucions: | 1Universidade Federal de Santa Catarina, Departamento de Quimica, Florianopolis, Santa Catarina. Brasil 2Universidade Federal de Santa Catarina, Departamento de Bioquimica, Florianopolis, Santa Catarina. Brasil |
| Any: | 2006 |
| Període: | Jul |
| Volum: | 29 |
| Número: | 4 |
| Paginació: | 844-855 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | This article provides an overview on the recent achievements to combat Gram-positive bacteria and the mechanisms related to antimicrobial activity and bacterial resistance. Selected synthetic methodologies to access structurally diverse bioactive compounds are presented in order to emphasize the most important substances currently developed to overcome multiresistant strains. The main properties of vancomycin and related glycopeptide antibiotics are also discussed as a background to understanding the design of new chemotherapeutic agents |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Microbiología, Bacterias Gram positivas, Resistencia bacteriana, Vancomicina |
| Keyword: | Chemistry, Medicinal chemistry, Microbiology, Gram positive bacteria, Bacterial resistance, Vancomycin |
| Text complet: | Texto completo (Ver HTML) |
