| Revista: | Quimica nova |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000313352 |
| ISSN: | 0100-4042 |
| Autors: | Ali, Syed Mashhood1 Maheshwari, Arti Asmat, Fahmeena Koketsu, Mamoru2 |
| Institucions: | 1Aligarh Muslim University, Department of Chemistry, Aligarh, Uttar Pradesh. India 2Gifu University, Life Science Research Center, Gifu. Japón |
| Any: | 2006 |
| Període: | Jul |
| Volum: | 29 |
| Número: | 4 |
| Paginació: | 685-688 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | A detailed NMR (¹H , COSY, ROESY) spectroscopic study of complexation of enalapril maleate with beta-cyclodextrin was carried out. The ¹H NMR spectrum of enalapril maleate confirmed the existence of cis-trans equilibrium in solution, possibly due to hindered rotation along the amide bond. The cis-trans ratio remained almost the same in the presence of beta-cyclodextrin but in one case it was found significantly different which suggests a catalytic role of beta-cyclodextrin in the isomerization. ¹H NMR titration studies confirmed the formation of an enalapril-beta-cyclodextrin inclusion complex as evidenced by chemical shift variations in the proton resonances of both the host and the guest. The stoichiometry of the complex was determined to be 2:1 (guest: host). The mode of penetration of the guest into the beta-cyclodextrin cavity as well as the structure of the complex were established using ROESY spectroscopy |
| Disciplines | Química |
| Paraules clau: | Química farmacéutica, Maleato de enalapril, Beta-ciclodextrina, Complejación, Resonancia magnética nuclear |
| Keyword: | Chemistry, Medicinal chemistry, Enalapril maleate, Beta-cyclodextrin, Nuclear magnetic resonance, Complexation |
| Text complet: | Texto completo (Ver HTML) |
