| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000400788 |
| ISSN: | 0074-0276 |
| Autors: | Ngai, Michelle1 McDowell, Mary Ann1 |
| Institucions: | 1University of Notre Dame, Eck Institute for Global Health, South Bend, Indiana. Estados Unidos de América |
| Any: | 2017 |
| Període: | Ene |
| Volum: | 112 |
| Número: | 1 |
| Paginació: | 1-7 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Insects are considered pests globally, implicated in the destruction of agricultural fields and transmission of pathogens that cause deadly human diseases, such as dengue, Zika and malaria. The diversity of the insecticide arsenal has remained stagnant for decades, but the recent rise of insecticide resistance fueled the discovery of novel modes of action, and the power of genomics has reinvigorated this search. This review discusses the importance of comparative and functional insect genomics in the identification of potential gene targets for an insecticidal mode of action with low off-target toxicity. Due to the global participation in the sequencing and annotation of insect genomes, the targeting of specific genes with molecular tools like RNAi and CRISPR/Cas9 for genome engineering and consequent functional identification and validation has become more efficient. While there are multiple avenues to explore for insecticidal candidates, this review identifies G-protein coupled receptors as attractive targets, and hones in on the octopamine and dopamine receptors due to their potential |
| Disciplines | Biología |
| Paraules clau: | Insectos, Biotecnología, Salud pública, Insecticidas, Genómica, Proteína G, Receptores acoplados |
| Keyword: | Biology, Insects, Biotechnology, Public health, Insecticides, Genomics, G proteins, Coupled receptors |
| Text complet: | Texto completo (Ver HTML) |
