| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000446427 |
| ISSN: | 0074-0276 |
| Autores: | Costa-Filho, Rubens Carmo1 Castro-Faria Neto, Hugo Caire2 Mengel, José2 Pelajo Machado, Marcelo2 Martins, Marco Aurélio2 Leite, Erica Távora3 Mendonca-Filho, Hugo Tannus4 Souza, Tatiana de Arruda Campos Brasil de5 Bello, Gonzalo Bentacor2 Leite, José Paulo Gagliardi2 |
| Instituciones: | 1Americas Servicos Medicos, Hospital Pro-Cardíaco, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 3Instituto Nacional do Cancer, Rio de Janeiro. Brasil 4United-Health Group, Politicas de Saude, Rio de Janeiro. Brasil 5Fundacao Oswaldo Cruz, Instituto Carlos Chagas, Curitiba, Parana. Brasil |
| Año: | 2021 |
| Volumen: | 116 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, prospectivo |
| Resumen en inglés | Coronaviruses can cause a diverse array of clinical manifestations, from fever with symptoms of the common cold to highly lethal severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS). SARS-CoV-2, the coronavirus discovered in Hubei province, China, at the end of 2019, became known worldwide for causing coronavirus disease 2019 (COVID-19). Over one year’s time period, the scientific community has produced a large bulk of knowledge about this disease and countless reports about its immune-pathological aspects. This knowledge, including data obtained in postmortem studies, points unequivocally to a hypercoagulability state. However, the name COVID-19 tells us very little about the true meaning of the disease. Our proposal is more comprehensive; it intends to frame COVID-19 in more clinical terminology, making an analogy to viral haemorrhagic fever (VHF). Thus, we found irrefutable evidence in the current literature that COVID-19 is the first viral disease that can be branded as a viral thrombotic fever. This manuscript points out that SARS-CoV-2 goes far beyond pneumonia or SARS. COVID-19 infections promote remarkable interactions among the endothelium, coagulation, and immune response, building up a background capable of promoting a “thrombotic storm,” much more than a “cytokine storm.” The importance of a viral protease called main protease (Mpro) is highlighted as a critical component for its replication in the host cell. A deeper analysis of this protease and its importance on the coagulation system is also discussed for the first time, mainly because of its similarity with the thrombin and factor Xa molecules, as recently pointed out by structural comparison crystallographic structures |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Virus, COVID-19, SARS-CoV-2, Endotelio, Inflamación, Coagulación, Hipercoagulabilidad, Trombosis, Tromboelastometría |
| Keyword: | Hematology, Virus, Endothelium, COVID-19, SARS-CoV-2, Inflammation, Coagulation, Hypercoagulability, Thrombosis, Thromboelastometry |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
