| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459431 |
| ISSN: | 0074-0276 |
| Autores: | Lima, Ana Carolina Bastos de1 Mendes, Veronica Gonçalves2 Ferreira, Roberto Rodrigues1 Nisimura, Lindice Mitie1 Horita, Samuel Iwao Maia1 Veloso, Henrique H2 Costa, Andréa R2 da Silva, Gilberto Marcelo S2 Sangenis, Luiz Henrique C2 Holanda, Marcelo T2 Rimolo, Lorena3 Cunha, Ademir B3 Garzoni, Luciana Ribeiro1 Hasslocher Moreno, Alejandro Marcel2 Mediano, Mauro Felippe F2 Moreira, Otacílio da Cruz1 Britto, Constança1 Saraiva, Roberto M2 |
| Instituciones: | 1Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 2Fundacao Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro. Brasil 3Universidade Federal Fluminense, Hospital Universitario Antonio Pedro, Niteroi, Rio de Janeiro. Brasil |
| Año: | 2023 |
| Volumen: | 118 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | A positive Trypanosoma cruzi polymerase chain reaction (PCR) is associated with a worse prognosis in patients with chronic Chagas disease (CD). OBJECTIVES To study the association of clinical, electrocardiographic, and echocardiographic characteristics and biomarker blood levels with positive T. cruzi PCR in chronic CD. METHODS This is a single-centre observational cross-sectional study. Positive T. cruzi PCR association with clinical, electrocardiographic, and echocardiographic characteristics, and biomarker blood levels were studied by logistic regression analysis. p values < 0.05 were considered significant. FINDINGS Among 333 patients with chronic CD (56.4% men; 62 ± 10 years), T. cruzi PCR was positive in 41.1%. Stepwise multivariate logistic regression showed an independent association between positive T. cruzi PCR and diabetes mellitus {odds ratio (OR) 0.53 [95% confidence interval (CI) 0.30-0.93]; p = 0.03}, right bundle branch block [OR 1.78 (95% CI 1.09-2.89); p = 0.02], and history of trypanocidal treatment [OR 0.13 (95% CI 0.04-0.38); p = 0.0002]. Among patients with a history of trypanocidal treatment (n = 39), only four (10%) patients had a positive T. cruzi PCR. MAIN CONCLUSIONS Among several studied parameters, only diabetes mellitus, right bundle branch block, and history of trypanocidal treatment showed an independent association with positive T. cruzi PCR. History of trypanocidal treatment was a strong protective factor against a positive T. cruzi PCR |
| Disciplinas: | Medicina |
| Palabras clave: | Parasitología, Diagnóstico, Enfermedad de Chagas, Técnicas de diagnóstico, Reacción en cadena de la polimerasa (PCR), Biomarcadores, Trypanosoma cruzi |
| Keyword: | Parasitology, Diagnosis, Chagas disease, Diagnostic techniques, Polymerase chain reaction (PCR), Biomarkers, Trypanosoma cruzi |
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