| Revista: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000400866 |
| ISSN: | 0074-0276 |
| Autores: | Gasparotto, Juciano1 Kunzler, Alice1 Senger, Mario Roberto2 Souza, Celeste da Silva Freitas de2 Simone, Salvatore Giovanni de2 Bortolin, Rafael Calixto1 Somensi, Nauana1 Dal Pizzol, Felipe3 Moreira, José Claudio Fonseca1 Abreu-Silva, Ana Lucia4 Calabrese, Katia da Silva2 Silva-Junior, Floriano Paes2 Gelain, Daniel Pens1 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Porto Alegre, Rio Grande do Sul. Brasil 2Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil 3Universidade do Extremo Sul Catarinense, Programa de Pos-graduacao em Ciencias da Saude, Criciuma, Santa Catarina. Brasil 4Universidade Estadual do Maranhao, Departamento de Patologia, Sao Luis, Maranhao. Brasil |
| Año: | 2017 |
| Periodo: | Feb |
| Volumen: | 112 |
| Número: | 2 |
| Paginación: | 146-154 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed. FINDINGS In liver, L. amazonensis caused thiol oxidation and nitrotyrosine formation; SOD activity and SOD2 protein content were increased while SOD1 protein content decreased. The content of the cytokines IL-1β, IL-6, TNF-α, and the receptor of advanced glycation endproducts (RAGE) increased in liver. Treatment with the antioxidant N-acetyl-cysteine (20 mg/kg b.w) for five days inhibited oxidative stress parameters. MAIN CONCLUSIONS L. amazonensis induces significant alterations in the redox status of liver but not in other organs. Acute antioxidant treatment alleviates oxidative stress in liver, but it had no effect on pro-inflammatory markers. These results indicate that the pathobiology of leishmaniasis is not restricted to the cutaneous manifestations and open perspectives for the development of new therapeutic approaches to the disease, especially for liver function |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Bioquímica, Parasitología, Infección experimental, Daño hepático, Leishmania amazonensis, Antioxidantes, N-acetilcisteína |
| Keyword: | Medicine, Experimental medicine, Biochemistry, Parasitology, Experimental infection, Liver damage, Leishmania amazonensis, Antioxidants, N-acetylcysteine |
| Texto completo: | Texto completo (Ver HTML) |
