The Effect of Added Dead Space on Optimal Neuro-Muscular Drive and Respiratory Signals under Hypercapnia



Título del documento: The Effect of Added Dead Space on Optimal Neuro-Muscular Drive and Respiratory Signals under Hypercapnia
Revista: Journal of applied research and technology
Base de datos: PERIÓDICA
Número de sistema: 000380485
ISSN: 1665-6423
Autors: 1
1
2
Institucions: 1Feng Chia University, Department of Automatic Control Engineering, Taichung. Taiwán
2Feng Chia University, Office of Physical Education, Taichung. Taiwán
Any:
Període: Dic
Volum: 12
Número: 6
Paginació: 1003-1013
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The problem concerning the nature and the function of the dead space is of basic importance for the full comprehension of the respiratory physiology and pathophysiology. To study the effect of an imposed external dead space on the optimal respiratory control system, we simulated the optimal neuro-muscular drive and respiratory signals, including instantaneous airflow and lung volume profiles, with dead space loading under hypercapnia. The dead space measurement model by Gray was employed and the human respiratory control simulator based on an optimality hypothesis was implemented. The ventilatory control simulations were performed with external dead space loading of 0, 0.4 and 0.8 liters under rest condition (Pico2=0%) and CO2 inhalation of 3% to 7%. The optimization of the respiratory signals and model behavior of the optimal respiratory control under dead space loading and hypercapnia were verified and found to be in general agreement with experimental findings
Disciplines Ingeniería,
Medicina
Paraules clau: Fisiología humana,
Ingeniería biomédica,
Fisiología respiratoria,
Control respiratorio,
Señal respiratoria,
Espacio muerto,
Hipercapnia
Keyword: Engineering,
Medicine,
Human physiology,
Biomedical engineering,
Respiratory physiology,
Respiratory control,
Respiratory signal,
Dead space,
Hypercapnia
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