| Revista: | Jornal brasileiro de pneumologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297465 |
| ISSN: | 1806-3713 |
| Autors: | Rubin, Adalberto Sperb1 Pelegrin, Liliana G Perin, Christiano Leite, Mauricio Roux Silva, Luiz Carlos Correa da |
| Institucions: | 1Complexo Hospitalar de Santa Casa de Porto Alegre, Pavilhao Pereira-Filho, Porto Alegre, Rio Grande do Sul. Brasil |
| Any: | 2004 |
| Període: | May-Jun |
| Volum: | 30 |
| Número: | 3 |
| Paginació: | 195-200 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: Short-acting beta2 agonists delivered by metered-dose inhaler (MDIs) are the drugs usually used for the reversal of methacholine-induced bronchoconstriction. The b2 agonists that are delivered by dry-powder inhaler (DPI) can be an efficacious option. OBJECTIVE: To evaluate the effectiveness and speed of action of salbutamol delivered by DPI (Pulvinal; Butovent®), in comparison to salbutamol delivered by MDI, in reversing methacholine-induced bronchoconstriction. METHOD: Sixty successive methacholine-induced bronchoconstriction patients who presented a decrease of at least 20% in forced expiratory volume (FEV1) were evaluated prospectively. Of these 60 patients, we randomized 30 (first group) to receive 200 mcg of salbutamol by MDI and 30 (second group) to receive 200 mcg of salbutamol by DPI (Pulvinal). Both drugs were administered with the objective of reversing bronchoconstriction during the final phase of a bronchoprovocation test. The FEV1 values obtained at 1 and 5 minutes after bronchodilator administration were evaluated. RESULTS: The groups were comparable in gender distribution, age, weight, dose level provoking a 20% drop in FEV1 (first group: 1.3 mg; second group: 1.19 mg; p = 0.79) and post-methacholine FEV1 (first group: 2.03 l; second group: 1.99 l; p = 0.87), with no statistically significant differences between the two groups. In the first group (MDI), the mean increase in FEV1 was 16.2% (at 1 minute) and 22.2% (at 5 minutes), and in the second group (DPI) it was 17% (at 1 minute) and 23.6% (at 5 minutes). There was no statistically significant difference between the groups (p = 0.8). CONCLUSION: The beta2-agonists delivered by DPI (Pulvinal) present the same bronchodilator efficacy and speed of action as do those delivered by the more traditional MDI method |
| Resumen en portugués | RESULTADOS: Os grupos foram pareados por sexo, idade, peso, altura, dose provocativa causadora de queda de 20% no VEF1 (primeiro grupo: 1,3 mg ; segundo grupo: 1,19 mg; p = 0,79) e VEF1 pós-metacolina (primeiro grupo: 2,03 l; segundo grupo: 1,99 l; p = 0,87), sem diferença significativa entre eles. O incremento médio do VEF1 foi de 16,2% (1 minuto) e 22,2% (5 minutos) no primeiro grupo e de 17% (1 minuto) e 23,6% (5 minutos) no segundo grupo, não havendo diferença estatística entre eles (p = 0,8). CONCLUSÕES: Os b2-agonistas administrados através de inalador de pó seco (pulvinal) apresentam a mesma eficácia broncodilatadora e rapidez de ação que no tradicional método por nebulímetro pressurizado |
| Disciplines | Medicina |
| Paraules clau: | Farmacología, Neumología, Terapéutica y rehabilitación, Albuterol, Metacolina, Terapia respiratoria, Broncodilatadores, Asma, Inhalación, Dosificación |
| Keyword: | Medicine, Pharmacology, Pneumology, Therapeutics and rehabilitation, Albuterol, Methacholine, Respiratory therapy, Bronchodilators, Asthma, Inhalation, Dosage |
| Text complet: | Texto completo (Ver HTML) |
