| Revista: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297240 |
| ISSN: | 1676-2444 |
| Autors: | Lima, Jose Carlos C1 Moreira, Agnaluce Lima, Daniela2 Correia, Luis C. L3 |
| Institucions: | 1Laboratorio de Patologia Clinica, Salvador, Bahia. Brasil 2Hospital Roberto Santos, Salvador, Bahia. Brasil 3Universidade Federal da Bahia, Salvador, Bahia. Brasil |
| Any: | 2005 |
| Període: | Feb |
| Volum: | 41 |
| Número: | 1 |
| Paginació: | 15-19 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: High-sensitivity c-reactive protein (hs-CRP) is an established risk predictor in primary prevention. Among available laboratory methods, enzyme linked immunosorbent assay (ELISA) and nephelometry are the most validated for this clinical application. Immunoluminometry is another high-sensitivity method of hs-CRP, with definitive prognostic value in acute coronary syndromes. However, it lacks validation for cardiovascular risk prediction in the outpatient setting, whose hs-CRP values are in a lower range in relation to unstable patients. OBJECTIVE: In an outpatient setting, test the hypothesis that the immunoluminometric method has enough accuracy to measure hs-CRP and classify individuals according to cardiovascular risk. METHOD: C-reactive protein was measured by the methods of immunoluminometry and nephelometry in 152 serum samples obtained from different outpatient subjects. Taken nephelometry as a gold-standard, performance of the immunoluminometric method was evaluated. RESULTS: There was a strong linear association between the two methods, according to the correlation coefficient (r = 0.996; p < 0.001) and regression coefficient (beta = 0.94, 95% C.I. = 0.92-0.95, p < 0.001). The mean difference between the two methods was - 0.22 ± 0.4mg/l. In 97% of the subjects, there was agreement between the methods in definition of low risk (hs-CRP < 1mg/l), intermediate risk (hs-CRP = 1-3mg/l) or high cardiovascular risk (hs-CRP > 3mg/l) - kappa = 0.96; p < 0.001. CONCLUSION: The immunoluminometric method of hs-CRP represents an alternative to nephelometry for the assessment of cardiovascular risk in an outpatient population |
| Resumen en portugués | CONCLUSÃO: A medida de PCR-as por quimioluminescência representa uma alternativa ao método nefelométrico na avaliação de risco cardiovascular de indivíduos ambulatoriais |
| Disciplines | Medicina |
| Paraules clau: | Diagnóstico, Sistema cardiovascular, Proteína C reactiva, Quimioluminiscencia, Factores de riesgo, Nefelometria |
| Keyword: | Medicine, Cardiovascular system, Diagnosis, C reactive protein, Chemiluminescence, Risk factors, Nephelometry |
| Text complet: | Texto completo (Ver HTML) |
