| Revista: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297081 |
| ISSN: | 1676-2444 |
| Autores: | Resio, Maria Paula Zanetti1 Souza, Ana Maria de Toloi, Maria Regina Torqueti Gregorio, Zita Maria de Oliveira Montes, Marlise Bonetti Agostinho Franceschini, Silvio Antonio2 Castro, Fabiola Attie de |
| Instituciones: | 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas, Ribeirao Preto, Sao Paulo. Brasil 2Universidade de Sao Paulo, Sistema Integrado de Saude, Sao Paulo. Brasil |
| Año: | 2003 |
| Volumen: | 39 |
| Número: | 4 |
| Paginación: | 295-300 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | BACKGROUND: In literature there are many studies about iron status in children, adolescents and fertile women, but investigations of iron stores and erythrocyte parameters variation after hormone replacement therapy (HRT) are rare. Elevated iron stores, oxidative stress, and estrogen deficiency may place premenopausal and menopausal women in a risk of developing heart disease and cancer. OBJECTIVE: To evaluate the effect of HRT in erythrogram and iron status in premenopausal and menopausal women. METHODS: Hematological indices and iron status were assessed by erythrogram, serum ferritin, iron and transferrin iron-binding capacity (TIBC) in 30 pre- and menopausal women before and after HRT with medroxiprogesterone and estradiol. The blood exam, serum iron and iron-binding capacity were determined by laboratory classic methods, while ferritin was measured by quimiluminescent assay. RESULTS: HRT use was followed by a significant reduction in the absolute number of erythrocyte, an increase of hematimetric indexes and a trend towards a reduction of serum iron levels and TIBC. No alterations on serum ferritin and transferrin saturation index were detected after HRT. DISCUSSION AND CONCLUSION: In the present study, alterations in red cell and iron parameters, which could impair the use of HRT in premenopausal and menopausal women, were not observed. Our results suggest that HRT in premenopausal women are beneficial to iron status, maintaining normal iron stores and promoting elevation of red cells indexes |
| Resumen en portugués | Os resultados sugerem que a TRH exerceu efeito benéfico sobre o estado férrico nas mulheres no climatério deste estudo, mantendo os estoques de ferro normais e promovendo a elevação dos índices hematimétricos |
| Disciplinas: | Medicina |
| Palabras clave: | Ginecología y obstetricia, Hematología, Terapéutica y rehabilitación, Ferritina, Hierro, Hormonas, Climaterio, Premenopausia |
| Keyword: | Medicine, Gynecology and obstetrics, Hematology, Therapeutics and rehabilitation, Ferritin, Iron, Hormones, Climacteric, Premenopause |
| Texto completo: | Texto completo (Ver HTML) |
