| Revista: | Jornal brasileiro de patologia e medicina laboratorial |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000297066 |
| ISSN: | 1676-2444 |
| Autors: | Dusse, Luci Maria Sant'Ana1 Vieira, Lauro Mello Carvalho, Maria das Gracas |
| Institucions: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil |
| Any: | 2003 |
| Període: | Jul-Sep |
| Volum: | 39 |
| Número: | 3 |
| Paginació: | 199-202 |
| País: | Brasil |
| Idioma: | Portugués |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | Preeclampsia is associated to a generalized vasoconstriction, clot abnormalities and fibrin deposition within placenta microcirculation. The presence of fibrin hampers the placenta perfusion contributing to prematurity, fetal low weight and neonates' mortality. D-Dimers (D-Di) are the products of degradation of cross-linked fibrin by plasmin. Increased plasma levels of D-Di may indicate either an exacerbated fibrin formation or an increase in plasmin activity. The present work aimed to assess and compare the plasma levels of D-Di (Elisa, Stago) in normal women (controls, n = 26), preeclamptic women with mild and moderate symptoms (n = 23) and preeclamptic women with severe symptoms (n = 20), in order to investigate the possible usefulness of this laboratory marker for diagnosis and/or prognosis of this disease. The averages and standard deviations observed for the three groups were 1,146.6 ± 311.2; 1,060.3 ± 259.2 and 1,497.8 ± 435.3ng/ml, respectively. A significant difference for D-Di levels was observed between pregnant women with severe and mild/moderate symptoms (p < 0.001) and between the former group and controls (p < 0.01). The results suggest an exacerbated clotting in pregnant women with severe symptoms and a suitable activity of fibrinolytic system, contributing to removing the excessive amount of fibrin. D-Di may be considered a potential tool for assessing the disease severity |
| Resumen en portugués | Considerando-se os resultados obtidos, pode-se sugerir que há uma exacerbação da coagulação na forma grave da DHEG e que o sistema fibrinolítico está atuante buscando remover a excessiva quantidade de fibrina formada. O D-Di constitui uma potencial ferramenta para se avaliar a gravidade da doença |
| Disciplines | Medicina |
| Paraules clau: | Ginecología y obstetricia, Sistema cardiovascular, Hipertensión arterial, Embarazo, Dímero D, Plasma, Preeclampsia |
| Keyword: | Medicine, Cardiovascular system, Gynecology and obstetrics, Arterial hypertension, Pregnancy, D Dimer, Plasma, Preeclampsia |
| Text complet: | Texto completo (Ver HTML) |
