Revista: | International braz j urol |
Base de datos: | PERIÓDICA |
Número de sistema: | 000434784 |
ISSN: | 1677-5538 |
Autors: | Suyama, Taisuke1 Kanbe, Shigeki2 Maegawa, Masanobu1 Shimizu, Hirofumi1 Nakajima, Koichi2 |
Institucions: | 1Sanaikai General Hospital, Department of Genitourinary, Saitama, Misato. Japón 2Toho University, Omori Medical Center, Funabashi, Chiba. Japón |
Any: | 2019 |
Període: | May-Jun |
Volum: | 45 |
Número: | 3 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | Objectives: To investigate whether Glasgow Prognostic Score has prognostic significance in patients with upper urinary urothelial carcinoma. Patients and methods: We retrospectively reviewed the clinical records of 74 patients with upper urinary urothelial carcinoma. We set the cut-off value for C-reactive protein as 1.0mg/dL, and 3.5mg/dL for albumin as Glasgow Prognostic Score. Their blood data including albumin and C-reactive protein for Glasgow Prognostic Score and cytokeratin 19 fragment 21-1 as a tumor marker were measured before starting treatment. The patients were stratified into three groups with Glasgow Prognostic Score: The Group-1, albumin ≥3.5g/dL and C-reactive protein < 1.0mg/dL; Group-2, albumin < 3.5g/dL or C-reactive protein ≥1.0mg/dL; Group-3, albumin < 3.5g/dL and C-reactive protein ≥1.0mg/dL. Results: The median follow-up for all patients was 26.9 months (range: 10.9-91.1 months), during which 37 (50%) patients died. There was a significant difference in the estimated survival rate among the 3 groups stratified by Glasgow Prognostic Score. The estimated survival rate in the Group-1 was significantly higher than those in Groups 2 and 3. In the univariate analysis C-reactive protein, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were significant predictors of overall survival. On the multivariate analysis, serum cytokeratin 19 fragment 21-1 and Glasgow Prognostic Score were independently associated with shorter overall survival. Conclusion: Our review suggests Glasgow Prognostic Score may play as a prognostic predictor for upper urinary urothelial carcinoma |
Disciplines | Medicina |
Paraules clau: | Urología, Oncología, Diagnóstico, Carcinoma urotelial, Biomarcadores, Proteína C reactiva, Queratina-19, Valor diagnóstico |
Keyword: | Urology, Oncology, Diagnosis, Urothelial carcinoma, Biomarkers, C reactive protein, Keratin-19, Prognostic value |
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