| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434630 |
| ISSN: | 1677-5538 |
| Autors: | Azambuja, Alan A1 Engroff, Paula2 Silva, Bruna T1 Zorzetti, Roberta C. S1 Morrone, Fernanda B3 |
| Institucions: | 1Pontificia Universidade Catolica do Rio Grande do Sul, Escola de Medicina, Porto Alegre, Rio Grande do Sul. Brasil 2Pontificia Universidade Catolica do Rio Grande do Sul, Instituto de Geriatria e Gerontologia, Porto Alegre, Rio Grande do Sul. Brasil 3Pontificia Universidade Catolica do Rio Grande do Sul, Escola de Ciencias da Saude, Porto Alegre, Rio Grande do Sul. Brasil |
| Any: | 2020 |
| Període: | May-Jun |
| Volum: | 46 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. The aim of this study was to evaluate the risk of recurrence and overall survival related to the expression of nuclear factor kappa-B (NF-κB), transglutaminase 2 (TG2) and excision repair cross-complementation group 1 (ERCC1) in patients with TGCT treated with platinum combinations. Patients and Methods: A retrospective study was performed with TGCT patients treated with platinum-based chemotherapy. Immunohistochemical analysis was performed and the expression was correlated with clinical and laboratory data. Results: Fifty patients were included, the mean age was 28.4 years (18 to 45), and 76% were non-seminoma. All patients were treated with standard cisplatin, etoposide and bleomycin or cisplatin, and etoposide. Patient’s analyzed immunodetection for NF-κB, TG2, and ERCC1 were positive in 76%, 54% and 42%, respectively. Multivariate analysis identified that positive expressions to ERCC1 and NF-κB are independent risk factors for higher recurrence TGCT after chemotherapy (RR 2.96 and 3.16, respectively). Patients with positive expression of ERCC1 presented a poor overall survival rate for 10-year follow (p=0.001). Conclusions: The expression of ERCC1 and NF-κB give a worse prognosis for relapse, and only ERCC1 had an influence on the overall survival of TGCT patients treated with platinum-based chemotherapy. These may represent markers that predict poor clinical outcome and response to cisplatin |
| Disciplines | Medicina |
| Paraules clau: | Urología, Oncología, Farmacología, Neoplasias, Testículos, Transglutaminasa, Cisplatino |
| Keyword: | Urology, Oncology, Pharmacology, Neoplasms, Testicles, Transglutaminase, Cisplatin |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
