| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434793 |
| ISSN: | 1677-5538 |
| Autors: | Leitsmann, Conrad1 Thelen, Paul1 Schmid, Marianne1 Meller, Johannes2 Sahlmann, Carsten-Oliver2 Meller, Birgit2 Trojan, Lutz1 Strauss, Arne1 |
| Institucions: | 1University Medical Center Goettingen, Department of Urology, Goettingen, Weende. Alemania 2University Medical Center Goettingen, Department of Nuclear Medicine, Goettingen, Weende. Alemania |
| Any: | 2019 |
| Període: | May-Jun |
| Volum: | 45 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Purpose: 68Ga-PSMA PET/CT imaging is a promising modality for the staging of recurrent prostate cancer (PCa). Current evidence suggests limited diagnostic value of the 68Ga-PSMA PET/CT in PSA-levels ≤0.3ng/mL. Experimental data have demonstrated an increase in PSMA-expression in PCa metastases by androgen deprivation in vitro. The aim of the current study was to investigate a possible enhancing effect of PSMA with low-dose androgen deprivation in patients with BCR and low PSA-levels. Materials and Methods: Five patients with PCa and BCR, following radical prostatectomy, underwent 68Ga-PSMA PET/CT. A consecutive 68Ga-PSMA PET/CT was performed 6 to 11 days after injection of 80mg of Degarelix (Firmagon®). We recorded PSA and testosterone serum-levels and changes of PSMA-uptake in 68Ga-PSMA PET/CT images. Results: Median PSA prior 68Ga-PSMA PET/CT was 0.27ng/mL. All patients had a decrease in testosterone serum levels from median 2.95μg/l to 0.16μg/l following Degarelix injection. We observed an increase in the standardized uptake value (SUV) in PSMA-positive lymphogenous and osseous lesions in two patients following androgen deprivation. In another two patients, no PSMA positive signals were detected in either the first or the second scan. Conclusion: Our preliminary results of this feasibility assessment indicate a possible enhancing effect of PSMA-imaging induced by low-dose ADT. Despite several limitations and the small number of patients, this could be a new approach to improve staging by 68Ga-PSMA PET/CT in PCa patients with BCR after primary therapy. Further prospective studies with larger number of patients are needed to validate our findings |
| Disciplines | Medicina |
| Paraules clau: | Urología, Oncología, Diagnóstico, Neoplasias, Próstata, Radioterapia, Metástasis, Tomografía por emisión de positrones, Imagenología por resonancia magnética |
| Keyword: | Urology, Oncology, Diagnosis, Neoplasms, Prostate, Radiotherapy, Metastasis, Positron emission tomography, Magnetic resonance imaging |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
