| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434812 |
| ISSN: | 1677-5538 |
| Autors: | Taheri, Maryam1 Tavasoli, Sanaz1 Shokrzadeh, Fatemeh1 Amiri, Fahimeh Bagheri1 Basiri, Abbas1 |
| Institucions: | 1Shahid Beheshti University of Medical Sciences, Urology and Nephrology Research Center, Teherán. Irán |
| Any: | 2019 |
| Període: | Mar-Abr |
| Volum: | 45 |
| Número: | 2 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Purpose: Hypercalciuria is one of the risk factors for calcium kidney stone formation (the most common type of urinary stones). Although vitamin D deficiency is prevalent among urolithiasis patients, the effect of vitamin D supplementation on urine calcium in these patients is still unclear. Materials and Methods: In this retrospective study, medical and laboratory tests records of 26 patients with recurrent calcium kidney stones and vitamin D deficiency treated with 50000IU vitamin D per week for 8-12 weeks were analyzed. The changes in 24-hour urine calcium (24-h Ca), serum 25-hydroxyvitamin D (25 (OH) D), serum parathormone (PTH), other 24-hour urine metabolites and calculated relative supersaturations of calcium oxalate (CaOxSS), calcium phosphate (CaPSS) and uric acid (UASS) were assessed. Moreover, correlations between changes in 24-h Ca and other aforementioned variables were assessed. Results: Serum 25 (OH) D and 24-h Ca increased after vitamin D supplementation, while serum PTH decreased (p < 0.001, for all analyses). The levels of 24-hour urine sodium and urea increased significantly (p = 0.005 and p = 0.031, respectively). The levels of CaOxSS and CaPSS increased, but the changes were not significant (p = 0.177, and p = 0.218, respectively). There were no correlations between the changes in 24-h Ca and serum 25 (OH) D or PTH. Conclusions: The result of current study suggests that although urine Ca increased in vitamin D supplemented patients, this increase was not associated with the increase in serum vitamin D and may be due to other factors such as dietary factors. Further randomized clinical trials considering other factors associated with urine Ca are warranted |
| Disciplines | Medicina |
| Paraules clau: | Metabolismo y nutrición, Nefrología, Hormona paratiroidea, Urolitiasis, Vitamina D |
| Keyword: | Metabolism and nutrition, Nephrology, Parathyroid hormone, Urolithiasis, Vitamin D |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
