| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434659 |
| ISSN: | 1677-5538 |
| Autors: | Johnston, Ashley W1 Longo, Thomas A1 Davis, Leah Gerber1 Zapata, Daniel1 Freedland, Stephen J2 Routh, Jonathan C1 |
| Institucions: | 1Duke University Medical Center, Division of Urologic Surgery, Durham, Carolina del Norte. Estados Unidos de América 2Cedars-Sinai Medical Center, Division of Urology, Los Angeles, California. Estados Unidos de América |
| Any: | 2020 |
| Període: | Ene-Feb |
| Volum: | 46 |
| Número: | 1 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Introduction: Tables predicting the probability of a positive bone scan in men with non-metastatic, castrate-resistant prostate cancer have recently been reported. We performed an external validation study of these bone scan positivity tables. Materials and Methods: We performed a retrospective cohort study of patients seen at a tertiary care medical center (1996-2012) to select patients with non-metastatic, castrate-resistant prostate cancer. ed data included demographic, anthropometric, and disease-specific data such as patient race, BMI, PSA kinetics, and primary treatment. Primary outcome was metastasis on bone scan. Multivariable logistic regression was performed using generalized estimating equations to adjust for repeated measures. Risk table performance was assessed using ROC curves. Results: We identified 6.509 patients with prostate cancer who had received hormonal therapy with a post-hormonal therapy PSA ≥2ng/mL, 363 of whom had non-metastatic, castrate-resistant prostate cancer. Of these, 187 patients (356 bone scans) had calculable PSA kinetics and ≥1 bone scan. Median follow-up after castrate-resistant prostate cancer diagnosis was 32 months (IQR: 19-48). There were 227 (64%) negative and 129 (36%) positive bone scans. On multivariable analysis, higher PSA at castrate-resistant prostate cancer (4.67 vs. 4.4ng/mL, OR=0.57, P=0.02), shorter time from castrate-resistant prostate cancer to scan (7.9 vs. 14.6 months, OR=0.97, P=0.006) and higher PSA at scan (OR=2.91, P <0.0001) were significantly predictive of bone scan positivity. The AUC of the previously published risk tables for predicting scan positivity was 0.72. Conclusion: Previously published risk tables predicted bone scan positivity in men with non-metastatic, castrate-resistant prostate cancer with reasonable accuracy |
| Disciplines | Medicina |
| Paraules clau: | Oncología, Urología, Próstata, Metástasis ósea, Radiología, Antígeno prostático específico |
| Keyword: | Oncology, Urology, Prostate, Bone metastasis, Radiology, Prostate specific antigen |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
