| Revista: | International braz j urol |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000434712 |
| ISSN: | 1677-5538 |
| Autores: | Xing, Jinchun1 Qin, Jiaxuan1 Cai, Zonglong3 Duan, Bo1 Bai, Peide1 |
| Instituciones: | 1Xiamen University, The First Affiliated Hospital, Xiamen, Fujian. China 2Fujian Medical University, Clinical Medical School, Xiamen, Fujian. China |
| Año: | 2019 |
| Periodo: | Sep-Dic |
| Volumen: | 45 |
| Número: | 5 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Purpose It has been reported that calcitonin receptor (CALCR) gene polymorphisms might be associated with calcium stone urolithiasis. Owing to mixed and inconclusive results, we conducted a meta-analysis to summarize and clarify this association. Materials and Methods A systematic search of studies on the association between CALCR gene polymorphisms and calcium stone urolithiasis susceptibility was conducted in databases. Results Odds ratios and 95% confidence intervals were used to pool the effect size. Five articles were included in our meta-analysis. Conclusions CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility. Well-designed studies with larger sample size and more subgroups are required to validate the risk identified in the current meta-analysis |
| Disciplinas: | Medicina |
| Palabras clave: | Urología, Genética, Bioquímica, Urolitiasis, Receptores químicos, Calcitonina, Polimorfismo genético, Patogénesis |
| Keyword: | Urology, Genetics, Biochemistry, Urolithiasis, Chemical receptors, Calcitonin, Genetic polymorphism, Pathogenesis |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
