The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Título del documento: The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000419975
ISSN: 1415-4757
Autors: 1
3
2
Institucions: 1Universidade Federal do Rio Grande do Sul, Programa de Pos-Graduacao em Genetica e Biologia Molecular, Porto Alegre, Rio Grande do Sul. Brasil
2Hospital de Clinicas de Porto Alegre, Laboratory of Basic Research and Advanced Investigations in Neurosciences, Porto Alegre, Rio Grande do Sul. Brasil
3Universidade Federal do Pampa, Interdisciplinary Research Center on Biotechnology-CIP-Biotec, Bage, Rio Grande do Sul. Brasil
Any:
Període: Sep
Volum: 41
Número: 3
Paginació: 515-532
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico
Resumen en inglés Research into the influence of the microbiome on the human body has been shedding new light on diseases long known to be multifactorial, such as obesity, mood disorders, autism, and inflammatory bowel disease. Although in - born errors of metabolism (IEMs) are monogenic diseases, genotype alone is not enough to explain the wide phenotypic variability observed in patients with these conditions. Genetics and diet exert a strong influence on the microbiome, and diet is used (alone or as an adjuvant) in the treatment of many IEMs. This review will describe how the effects of the microbiome on the host can interfere with IEM phenotypes through interactions with organs such as the liver and brain, two of the structures most commonly affected by IEMs. The relationships between treatment strat- egies for some IEMs and the microbiome will also be addressed. Studies on the microbiome and its influence in indi- viduals with IEMs are still incipient, but are of the utmost importance to elucidating the phenotypic variety observed in these conditions
Disciplines Medicina
Paraules clau: Metabolismo y nutrición,
Genética,
Terapéutica y rehabilitación,
Errores innatos del metabolismo,
Microbioma,
Microbiota,
Dieta,
Tratamiento
Keyword: Metabolism and nutrition,
Genetics,
Therapeutics and rehabilitation,
Inborn errors of metabolism,
Microbiota,
Microbiota,
Diet,
Treatment
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