| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459190 |
| ISSN: | 1415-4757 |
| Autors: | Oliveira, Ana Clara1 Fascineli, Maria Luiza1 Oliveira, Paula Martins de2 Gelfuso, Guilherme Martins2 Villacis, Rolando André Rios1 Grisolia, Cesar Koppe1 |
| Institucions: | 1Universidade de Brasília, Instituto de Ciencias Biologicas, Brasilia, Distrito Federal. Brasil 2Universidade de Brasilia, Faculdade de Ciencias da Saude, Brasilia, Distrito Federal. Brasil |
| Any: | 2023 |
| Volum: | 46 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | The toxic effects of venlafaxine (VLX) on aquatic organisms have already been verified and therefore are a proven matter of concern. Herein, we evaluated zebrafish embryos/adults after acute exposure to VLX. Embryos/larvae were exposed to different concentrations of VLX (100-1000 mg/L; 1.33 as a dilution factor), to evaluate mortality/developmental changos and to analyze biomarkers (0.002-100 mg/L). For adults, mortality, genotoxicity, and biomarkers were assessed in five different concentrations of VLX (1-100 mg/L). The median lethal concentration (LC50-168h) was 274.1 mg/L for embryos/larvae, and >100 mg/L for adults (LC50-96h). VLX decreased the heart rate frequency and caused premature hatching and lack of equilibrium in embryos/larvae exposed to different concentrations ranging from 100 to 562.5 mg/L. The activity of acetylcholinesterase (AChE) was inhibited in larvae exposed to 1, 25 and 100 mg/L. Glutathione-S-transferase (GST) activity was reduced in both larvae and adults after exposure to different concentrations, mainly at 25 mg/L. For both larvae and adults, lactate dehydrogenase (LDH) activity increased after 100 mg/L of VLX exposure. No DNA damage was observed in peripheral erythrocytes. Exposure to VLX may cause adverse effects on zebrafish in their early and adult life stages, interfering with embryo-larval development, and can induce physiological disturbances in adults |
| Disciplines | Biología |
| Paraules clau: | Peces, Danio rerio, Toxicidad, Venlafaxina, Genotoxicidad, Biomarcadores |
| Keyword: | Fish, Danio rerio, Venlafaxine, Biomarkers, Genotoxicity |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
