KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration
Título del documento: KDELR2 as a diagnostic and prognostic biomarker of bladder urothelial carcinoma and its correlation with immune infiltration
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000459186
ISSN: 1415-4757
Autors: 1
2
2
2
2
2
Institucions: 1Air Force Medical University, Department of Prosthodontics, Xi’an, Shaanxi. China
2Xi’an Jiaotong University, Honghui Hospital, Xi’an, Shaanxi. China
Any:
Volum: 46
Número: 3
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, analítico
Resumen en inglés KDELR2 has been reported as a promotive factor for the genesis and progression of several malignancies. However, it is uncertain how it affects bladder urothelial carcinoma (BLCA). Using data extracted from online databases, an enhanced expression of KDELR2 in BLCA tissues was verified. Overexpression of KDELR2 was correlated with advanced clinicopathologic characteristics and unfavourable prognosis of BLCA. Receiver operating characteristic analysis highlighted the potential diagnostic value of KDELR2. Univariate and multivariate logistic regression analyses further revealed the predictive effect of KDELR2 for the prognosis of BLCA. KDELR2 was primarily enriched in biological functions related to organization of the extracellular matrix. TIMER, ssGSEA and GEPIA analyses suggested that KDELR2 expression is positively related to the infiltration of macrophages, Th2 cells and neutrophils. Finally, knocking-down of KDELR2 in T24 cells resulted in reduced proliferation, migration and macrophages recruitment. These results suggest that KDELR2 overexpression is an indicator for poor prognosis of BLCA and it has the potential to be employed as an immunotherapy target for BLCA
Disciplines Medicina
Paraules clau: Oncología,
Diagnóstico,
Inmunología,
Cáncer,
Bioinformática,
Vejiga,
Carcinoma urotelial,
Infiltración
Keyword: Oncology,
Diagnosis,
Immunology,
Cancer,
Bioinformatics,
Bladder,
Urothelial carcinoma,
Infiltration
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