| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000459191 |
| ISSN: | 1415-4757 |
| Autors: | Fam, Bibiana Sampaio de Oliveira1 Vargas Pinilla, Pedro1 Paré, Pâmela1 Landau, Luane1 Viscardi, Lucas H1 Pissinatti, Alcides4 Falótico, Tiago2 Maestri, Renan3 Bortolini, Maria Cátira1 |
| Institucions: | 1Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil 2Universidade de Sao Paulo, Escola de Artes, Ciencias e Humanidades, Sao Paulo. Brasil 3Universidade Federal do Rio Grande do Sul, Departamento de Ecologia, Porto Alegre, Rio Grande do Sul. Brasil 4Centro de Primatologia do Rio de Janeiro, Rio de Janeiro. Brasil |
| Any: | 2023 |
| Volum: | 46 |
| Número: | 3 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, analítico |
| Resumen en inglés | The current study focuses on the investigation of AVPR2 (VTR2C) protein-coupled receptor variants specific to different primate taxa. AVPR2 is activated by the neurohormone AVP, which modulates physiological processes, including water homeostasis. Our findings reveal positive selection at three AVPR2 sites at positions 190, 250, and 346. Variation at position 250 is associated with human Congenital Nephrogenic Diabetes Insipidus (cNDI), a condition characterized by excessive water loss. Other 13 functional sites with potential adaptive relevance include positions 185, 202, 204, and 252 associated with cNDI. We identified SH3-binding motifs in AVPR2’s ICL3 and N-terminus domains, with some losses observed in clades of Cercopithecidae, Callitrichinae, and Atelidae. SH3-binding motifs are crucial in regulating cellular physiology, indicating that the differences may be adaptive. Co-evolution was found between AVPR2 residues and those in the AVP signal peptide/Neurophysin-2 and AQP2, other molecules in the same signaling cascade. No significant correlation was found between these Primates’ taxon-specific variants and the bioclimatic variables of the areas where they live. Distinct co-evolving amino acid sequences in functional sites were found in Platyrrhini and Catarrhini, which may have adaptive implications involving glucocorticoid hormones, suggesting varied selective pressures. Further studies are required to confirm these results |
| Disciplines | Biología |
| Paraules clau: | Vertebrados, Genética, Evolución y filogenia, Primates, AVPR2, Coevolución |
| Keyword: | Vertebrates, Genetics, Evolution and phylogeny, AVPR2, Primates, Coevolution |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
