| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418424 |
| ISSN: | 1415-4757 |
| Autors: | Silva-Sena, Geralda Gillian2 Camporez, Daniela1 Santos, Lígia Ramos dos3 Silva, Aline Sesana da2 Pimassoni, Lucia Helena Sagrillo4 Tieppo, Alessandra5 Batitucci, Maria do Carmo Pimentel6 Morelato, Renato Lírio5 Paula, Flavia de1 |
| Institucions: | 1Universidade Federal do Espirito Santo, Programa de Pos-Graduacao em Biotecnologia, Renorbio, Vitoria, Espirito Santo. Brasil 2Universidade Federal do Espirito Santo, Centro de Ciencias da Saude, Vitoria, Espirito Santo. Brasil 3Universidade Federal do Espirito Santo, Departamento de Ciencias Biologicas, Vitoria, Espirito Santo. Brasil 4Escola Superior de Ciencias da Santa Casa de Misericordia, Vitoria, Espirito Santo. Brasil 5Hospital da Santa Casa de Misericordia de Vitoria, Vitoria, Espirito Santo. Brasil 6Universidade Federal do Espirito Santo, Programa de Pos-graduacao em Ciencias Farmaceuticas, Vitoria, Espirito Santo. Brasil |
| Any: | 2018 |
| Període: | Jun |
| Volum: | 41 |
| Número: | 2 |
| Paginació: | 386-396 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | Human longevity is a polygenic and multifactorial trait. Pathways related to lifespan are complex and involve molecular, cellular, and environmental processes. In this analytical observational study, we evaluated the relationship between environment factors, oxidative stress status, DNA integrity level, and the association of FOXO3 (rs2802292), SOD2 (rs4880), APOE (rs429358 and rs7412), and SIRT1 (rs2273773) polymorphisms with longevity in oldest-old individuals from southeastern Brazil. We found an association between the FOXO3 GG genotype and gender. While lifestyle, anthropometric, and biochemical characteristics showed significant results, DNA damage and oxidative stress were not related to lifespan. We found that long-lived individuals with FOXO3 GT genotype had low levels of triglycerides. This study is the first to demonstrate that FOXO3 could be a candidate gene for longevity in the Brazilian population. These results are important in terms of provisions of health care for age-related diseases and lifespan, and provide insight for further research on epigenetic, gene regulation, and expression in oldest-old individuals |
| Disciplines | Medicina, Química |
| Paraules clau: | Genética, Bioquímica, Metabolismo y nutrición, Vida útil, Polimorfismos de nucleótido único (SNPs), Factores ambientales, Estrés oxidativo, Daño genómico |
| Keyword: | Genetics, Biochemistry, Metabolism and nutrition, Life span, Single nucleotide polymorphism (SNPs), Environmental factors, Oxidative stress, Genomic damage |
| Text complet: | Texto completo (Ver PDF) |
