Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Título del documento: Absence of TERT promoter mutations in colorectal precursor lesions and cancer
Revista: Genetics and molecular biology
Base de datos: PERIÓDICA
Número de sistema: 000417875
ISSN: 1415-4757
Autors: 1
1
2
3
4
Institucions: 1Hospital de Cancer de Barretos, Centro de Pesquisa de Oncologia Molecular, Barretos, Sao Paulo. Brasil
2Hospital de Cancer de Barretos, Departamento de Patología, Barretos, Sao Paulo. Brasil
3Hospital de Cancer de Barretos, Departamento de Endoscopia, Barretos, Sao Paulo. Brasil
4Universidade do Minho, Instituto de Pesquisa em Ciencias da Vida e da Saude, Braga. Portugal
Any:
Període: Mar
Volum: 41
Número: 1
Paginació: 82-84
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, analítico
Resumen en inglés Hotspot mutations (c.-124bp G > A and c.-146bp G > A) in the promoter region of the TERT gene have been recently described in several types of solid tumors, including glioma, bladder, thyroid, liver and skin neoplasms. However, knowledge with respect to colorectal precursor lesions and cancer is scarce. In the present study we aimed to determine the frequency of hotspot TERT promoter mutations in 145 Brazilian patients, including 103 subjects with precursor lesions and 42 with colorectal carcinomas, and we associated the presence of such mutations with the patients clinical-pathological features. The mutation analysis was conclusive in 123 cases, and none of the precursor and colorectal carcinoma cases showed TERT promoter mutations. We conclude that TERT mutations are not a driving factor in colorectal carcinogenesis
Disciplines Medicina
Paraules clau: Anatomía humana,
Genética,
Oncología,
Carcinoma colorrectal,
Mutaciones del promotor,
Lesiones precursoras,
Gen TERT
Keyword: Human anatomy,
Genetics,
Oncology,
Colorectal carcinoma,
TERT promoter mutations,
Precursor lesions,
TERT gene
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