Study of the thermal behavior in solid state of Mn(II)-Diclofenac Complex
Título del documento: Study of the thermal behavior in solid state of Mn(II)-Diclofenac Complex
Revista: Ecletica quimica
Base de datos:
Número de sistema: 000552618
ISSN: 0100-4670
Autores: 2
4
1
3
3
Instituciones: 1Universidade Estadual Paulista "Julio de Mesquita Filho", Escola de Ciências Farmacêuticas, Araraquara, São Paulo. Brasil
2Centro Universitário do Norte Paulista, Sao Jose do Rio Preto, Sao Paulo. Brasil
3Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Química, Araraquara, São Paulo. Brasil
4Instituto de Pesquisas Tecnológicas, Sao Paulo. Brasil
Año:
Volumen: 43
Número: 1
Paginación: 59-66
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Resumen en inglés The preparation, characterization and thermal behavior of Mn(II)-diclofenac solid-state complex was investigated by simultaneous TG/DTA and DTG curves, DSC, X-ray powder diffraction (XRD) and scanning electron microscopy (SEM) techniques. The thermal evaluation was carried out with sample masses of 2 and 5 mg, with the purpose of comparing the values of activation energy regarding dehydration, monotropic phase transition and thermal decomposition in both samples mass. The DSC curves were obtained in opened and with crimped lids crucibles of aluminum under oxygen purge gas and static air (without purge gas). The DTA and DSC curves show an exothermic peak between 150-180 °C depending on heating rate, which can be attributed to the monotropic non-reversible reaction. The activation energy (Ea/kJ mol-1) to dehydration, the monotropic phase transition and the first thermal decomposition step were determined by Capela-Ribeiro nonlinear isoconversional method. The activation energy under oxygen dynamic purge gas shows lower values compared to those obtained under static air.
Disciplinas: Química
Palabras clave: Química farmacéutica
Keyword: Medicinal chemistry
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