Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations
Título del documento: Simple and sensitive spectrophotometric methods for the determination of acebutolol hydrochloride in bulk sample and pharmaceutical preparations
Revista: Ecletica quimica
Base de datos: PERIÓDICA
Número de sistema: 000366951
ISSN: 0100-4670
Autors: 1
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Institucions: 1Karnatak University, Department of Chemistry, Dharwad. India
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Període: Abr-Jun
Volum: 33
Número: 2
Paginació: 37-40
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental
Resumen en inglés A direct, extraction-free spectrophotometric method has been developed for the determination of acebutolol hydrochloride (ABH) in pharmaceutical preparations. The method is based on ion-pair complex formation between the drug and two acidic dyes (sulphonaphthalein) namely bromocresol green (BCG) and bromothymol blue (BTB). Conformity to Beer's law enabled the assay of the drug in the range of 0.5-13.8 µg mL-1 with BCG and 1.8-15.9 µg mL-1 with BTB. Compared with a reference method, the results obtained were of equal accuracy and precision. In addition, these methods were also found to be specific for the analysis of acebutolol hydrochloride in the presence of excipients, which are co-formulated in the drug
Disciplines Química
Paraules clau: Química analítica,
Química farmacéutica,
Clorhidrato acebutolol,
Espectrofotometría,
Preparaciones farmacéuticas
Keyword: Chemistry,
Analytical chemistry,
Medicinal chemistry,
Acebutolol hydrochloride,
Spectrophotometry,
Pharmaceutical preparations
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