Anthropometric, biochemical and endothelial cardiovascular risk markers in subjects with metabolic syndrome: a control group comparison
Título del documento: Anthropometric, biochemical and endothelial cardiovascular risk markers in subjects with metabolic syndrome: a control group comparison
Revista: Diabetes internacional
Base de datos: PERIÓDICA
Número de sistema: 000422476
ISSN: 1856-965X
Autors: 1
2
1
1
3
4
1
1
Institucions: 1Universidad Central de Venezuela, Escuela de Medicina "José María Vargas", Caracas, Distrito Federal. Venezuela
2Universidad Central de Venezuela, Facultad de Medicina, Caracas, Distrito Federal. Venezuela
3Unidad Nacional de Educación "José Felix Ribas", San Juan de los Morros, Guárico. Venezuela
4Hospital Militar "Dr. Carlos Arvelo", Caracas, Distrito Federal. Venezuela
Any:
Volum: 4
Número: 1
Paginació: 82-86
País: Venezuela
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, analítico
Resumen en inglés The metabolic dysfunctions and diseases clustered under the Metabolic Syndrome (MS) definition are all progressive and lead to increases morbidity and mortality due to cardiovascular causes. Endothelial dysfunction is an important feature of metabolic syndrome. Endothelium is a complex endocrine organ able to produce a large quantity of substances such as Endothelin-1 a powerful vasoconstrictor and Nitric Oxide (NO) a vasodilator related to oxidative stress. The aim of this study was to evaluate cardiovascular risk markers in subjects with metabolic syndrome and compare against a control group. Material and Methods: We set in 9 groups with normal laboratory values and without metabolic syndrome diagnosis (control group) and performed a complete clinical evaluation including anthropometry measurements and cholesterol, tryacilglycerides, C-HDL, C-LDL, glucose (INVELAB), insulin, endothelin-1 and NO (Commercial Cayman and Calbiochem ELISA kit). Results: lower NO levels where observed in MS subjects compared to control leading to vasoconstriction, vascular wall abnormalities and hypertension in addition to resistance to insulin, overweight and dyslipidaemia may lead to increased endothelial dysfunction and cardiovascular disease in this patients. In the metabolic syndrome (MS) the pathologies alteration progresses in the time, towards a high morbidity and cardiovascular mortality. The endothelial dysfunction is a characteristic of the MS. Endothelium, is a complex structure that acts in the vascular remodeling and the liberation of active substances, such as Endotelina-1, a powerful vasoconstrictor and Nítric Oxide (NO), vasodilator associated to the oxidative presence of stress. The objective of this work was to evaluate the cardiovascular risk and endothelian markers in subjects with metabolic syndrome (n=9) compared to the control group (n=9). The subjects were evaluated by anthropometric..
Disciplines Medicina
Paraules clau: Metabolismo y nutrición,
Sistema cardiovascular,
Diagnóstico,
Síndrome metabólico,
Riesgo cardiovascular,
Endotelina-1,
Oxido nítrico,
Marcadores de riesgo
Keyword: Metabolism and nutrition,
Cardiovascular system,
Diagnosis,
Metabolic syndrome,
Cardiovascular risk,
Endothelin-1,
Nitric oxide,
Risk markers
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